Microarray evaluation of gene expression profiles in inflamed and healthy human dental pulp: the role of IL1beta and CD40 in pulp inflammation

V. Gatta, V. L. Zizzari, V. Dd ' Amico, L. Salini, M. D' Aurora, S. Franchi, I. Antonucci, M. T. Sberna, E. Gherlone, L. Stuppia, S. Tetè

Research output: Contribution to journalArticle

Abstract

Dental pulp undergoes a number of changes passing from healthy status to inflammation due to deep decay. These changes are regulated by several genes resulting differently expressed in inflamed and healthy dental pulp, and the knowledge of the processes underlying this differential expression is of great relevance in the identification of the pathogenesis of the disease. In this study, the gene expression profile of inflamed and healthy dental pulps were compared by microarray analysis, and data obtained were analyzed by Ingenuity Pathway Analysis (IPA) software. This analysis allows to focus on a variety of genes, typically expressed in inflamed tissues. The comparison analysis showed an increased expression of several genes in inflamed pulp, among which IL1β and CD40 resulted of particular interest. These results indicate that gene expression profile of human dental pulp in different physiological and pathological conditions may become an useful tool for improving our knowledge about processes regulating pulp inflammation.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume26
Issue number2
Publication statusPublished - Apr 1 2012

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Dental Pulp
Transcriptome
Inflammation
Microarray Analysis
Genes
Software
Gene Expression

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Microarray evaluation of gene expression profiles in inflamed and healthy human dental pulp : the role of IL1beta and CD40 in pulp inflammation. / Gatta, V.; Zizzari, V. L.; Dd ' Amico, V.; Salini, L.; D' Aurora, M.; Franchi, S.; Antonucci, I.; Sberna, M. T.; Gherlone, E.; Stuppia, L.; Tetè, S.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 26, No. 2, 01.04.2012, p. 45-50.

Research output: Contribution to journalArticle

Gatta, V, Zizzari, VL, Dd ' Amico, V, Salini, L, D' Aurora, M, Franchi, S, Antonucci, I, Sberna, MT, Gherlone, E, Stuppia, L & Tetè, S 2012, 'Microarray evaluation of gene expression profiles in inflamed and healthy human dental pulp: the role of IL1beta and CD40 in pulp inflammation', Journal of Biological Regulators and Homeostatic Agents, vol. 26, no. 2, pp. 45-50.
Gatta, V. ; Zizzari, V. L. ; Dd ' Amico, V. ; Salini, L. ; D' Aurora, M. ; Franchi, S. ; Antonucci, I. ; Sberna, M. T. ; Gherlone, E. ; Stuppia, L. ; Tetè, S. / Microarray evaluation of gene expression profiles in inflamed and healthy human dental pulp : the role of IL1beta and CD40 in pulp inflammation. In: Journal of Biological Regulators and Homeostatic Agents. 2012 ; Vol. 26, No. 2. pp. 45-50.
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