Abstract
Dental pulp undergoes a number of changes passing from healthy status to inflammation due to deep decay. These changes are regulated by several genes resulting differently expressed in inflamed and healthy dental pulp, and the knowledge of the processes underlying this differential expression is of great relevance in the identification of the pathogenesis of the disease. In this study, the gene expression profile of inflamed and healthy dental pulps were compared by microarray analysis, and data obtained were analyzed by Ingenuity Pathway Analysis (IPA) software. This analysis allows to focus on a variety of genes, typically expressed in inflamed tissues. The comparison analysis showed an increased expression of several genes in inflamed pulp, among which IL1β and CD40 resulted of particular interest. These results indicate that gene expression profile of human dental pulp in different physiological and pathological conditions may become an useful tool for improving our knowledge about processes regulating pulp inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 45-50 |
| Number of pages | 6 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 26 |
| Issue number | 2 |
| Publication status | Published - Apr 1 2012 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Microarray evaluation of gene expression profiles in inflamed and healthy human dental pulp : the role of IL1beta and CD40 in pulp inflammation. / Gatta, V.; Zizzari, V. L.; Dd ' Amico, V.; Salini, L.; D' Aurora, M.; Franchi, S.; Antonucci, I.; Sberna, M. T.; Gherlone, E.; Stuppia, L.; Tetè, S.
In: Journal of Biological Regulators and Homeostatic Agents, Vol. 26, No. 2, 01.04.2012, p. 45-50.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Microarray evaluation of gene expression profiles in inflamed and healthy human dental pulp
T2 - the role of IL1beta and CD40 in pulp inflammation
AU - Gatta, V.
AU - Zizzari, V. L.
AU - Dd ' Amico, V.
AU - Salini, L.
AU - D' Aurora, M.
AU - Franchi, S.
AU - Antonucci, I.
AU - Sberna, M. T.
AU - Gherlone, E.
AU - Stuppia, L.
AU - Tetè, S.
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Dental pulp undergoes a number of changes passing from healthy status to inflammation due to deep decay. These changes are regulated by several genes resulting differently expressed in inflamed and healthy dental pulp, and the knowledge of the processes underlying this differential expression is of great relevance in the identification of the pathogenesis of the disease. In this study, the gene expression profile of inflamed and healthy dental pulps were compared by microarray analysis, and data obtained were analyzed by Ingenuity Pathway Analysis (IPA) software. This analysis allows to focus on a variety of genes, typically expressed in inflamed tissues. The comparison analysis showed an increased expression of several genes in inflamed pulp, among which IL1β and CD40 resulted of particular interest. These results indicate that gene expression profile of human dental pulp in different physiological and pathological conditions may become an useful tool for improving our knowledge about processes regulating pulp inflammation.
AB - Dental pulp undergoes a number of changes passing from healthy status to inflammation due to deep decay. These changes are regulated by several genes resulting differently expressed in inflamed and healthy dental pulp, and the knowledge of the processes underlying this differential expression is of great relevance in the identification of the pathogenesis of the disease. In this study, the gene expression profile of inflamed and healthy dental pulps were compared by microarray analysis, and data obtained were analyzed by Ingenuity Pathway Analysis (IPA) software. This analysis allows to focus on a variety of genes, typically expressed in inflamed tissues. The comparison analysis showed an increased expression of several genes in inflamed pulp, among which IL1β and CD40 resulted of particular interest. These results indicate that gene expression profile of human dental pulp in different physiological and pathological conditions may become an useful tool for improving our knowledge about processes regulating pulp inflammation.
UR - http://www.scopus.com/inward/record.url?scp=84942743547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942743547&partnerID=8YFLogxK
M3 - Article
C2 - 23164326
AN - SCOPUS:84942743547
VL - 26
SP - 45
EP - 50
JO - Journal of Biological Regulators and Homeostatic Agents
JF - Journal of Biological Regulators and Homeostatic Agents
SN - 0393-974X
IS - 2
ER -