Microarray technology: A promising tool in nutrigenomics

Andrea Masotti, Letizia da Sacco, Gian Franco Bottazzo, Anna Alisi

Research output: Contribution to journalArticle

Abstract

Microarray technology is a powerful tool for the global evaluation of gene expression profiles in tissues and for understanding many of the factors controlling the regulation of gene transcription. This technique not only provides a considerable amount of information on markers and predictive factors that may potentially characterize a specific clinical picture, but also promises new applications for therapy. One of the most recent applications of microarrays concerns nutritional genomics. Nutritional genomics, known as nutrigenomics, aims to identify and understand mechanisms of molecular interaction between nutrients and/or other dietary bioactive compounds and the genome. Actually, many nutrigenomic studies utilize new approaches such as microarrays, genomics, and bioinformatics to understand how nutrients influence gene expression. The coupling of these new technologies with nutrigenomics promises to lead to improvements in diet and health. In fact, it may provide new information which can be used to ameliorate dietary regimens and to discover novel natural agents for the treatment of important diseases such as diabetes and cancer. This critical review gives an overview of the clinical relevance of a nutritional approach to several important diseases, and proposes the use of microarray for nutrigenomic studies.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalCritical Reviews in Food Science and Nutrition
Volume50
Issue number7
DOIs
Publication statusPublished - 2010

Keywords

  • Food
  • Gene expression
  • Macronutrients
  • Micronutrients
  • Nutritional genomics

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

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