Microbial Sensing and Regulation of Mucosal Immune Responses by Intestinal Epithelial Cells

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

For years, intestinal epithelial cells have been considered simply as a barrier to the external world. It is becoming clear, though, that they have multiple functions, from maintaining barrier integrity and participating in food degradation and absorption to deciphering signals coming from the outside world and responding accordingly. Indeed, under the unperturbed condition-steady state-they participate in keeping intestinal homeostasis, whereas during attack they alert the inner world of the presence of invaders. Epithelial cells comprise a family of very specialized cells whose characteristics and functions in relation to the microbiota are described in this chapter.

Original languageEnglish
Title of host publicationMucosal Immunology: Fourth Edition
PublisherElsevier Inc.
Pages571-590
Number of pages20
Volume1-2
ISBN (Print)9780124159754, 9780124158474
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • Antimicrobial peptides
  • Enterocytes
  • Epithelial cells
  • Goblet cells
  • Microbiota
  • Mucin
  • Paneth cells
  • Probiotics

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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