Ruolo del microbiota intestinale nelle malattie infiammatorie croniche intestinali: UN aggiornamento

Translated title of the contribution: Microbiota and inflammatory bowel disease: An update

Roberto De Sire, Claudia Talocco, Valentina Petito, Loris Riccardo Lopetuso, Cristina Graziani, Antonio Gasbarrini, Franco Scaldaferri

Research output: Contribution to journalReview article

Abstract

Summary. Over the last few years, the gut microbiota has been the focus of countless studies conducted both on mouse models and human population, aimed at analyzing its functions and interactions with the host, including nutrition, metabolic homeostasis, protection from infections and development of systemic and mucosal immunity both in inflammatory bowel disease (IBD) as well as other intestinal and extra-intestinal diseases. In IBD microbiota is impaired in overall composition and biodiversity, stability as well as functions. Microbial signature of IBD can be considered also a decrease in F. prausnitzii, increase of Proteonbacteria as well as the described increase of Candida albicans, Basidiomycota/Ascomycota ratio over Saccharomyces cerevisiae and of the Caudovirales over Microviridae. The indirect (through antibiotics, probiotics) and direct (through fecal microbiota transplantation) modulation of gut microbiota has relevant clinical implication in IBD management. In the near future role and clinical implication of gut microbiota characterization in the therapeutic personalized approach to IBD patients will eventually become clear.

Original languageItalian
Pages (from-to)570-573
Number of pages4
JournalRecenti Progressi in Medicina
Volume109
Issue number12
Publication statusPublished - Dec 1 2018

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this