Microbiota effects on cancer: From risks to therapies

Domenica Rea, Giovanni Coppola, Giuseppe Palma, Antonio Barbieri, Antonio Luciano, Paola Del Prete, Sabrina Rossetti, Massimiliano Berretta, Gaetano Facchini, Sisto Perdonà, Maria Caterina Turco, Claudio Arra

Research output: Contribution to journalReview article

Abstract

Gut microbiota, a group of 1014 bacteria, eukaryotes and virus living in gastrointestinal tract, is crucial for many physiological processes in particular plays an important role in inflammatory and immune reactions. Several internal and external factors can influence this population, and shifts in their composition, have been demonstrated to contribute and affect different diseases. During dysbiosis several bacteria related to inflammation, one of the most necessary factors in carcinogenesis; it has been shown that some bacterial strains through deregulation of different signals/pathways may affect tumor development through the production of many factors. Gut microbiota might be considered as a holistic hub point for cancer development: direct and indirect involvements have been studying in several neoplasms such as colon rectal cancer, hepatocellular carcinoma and breast cancer. This review discuss over the evidence of crosstalk between gut microbiota and cancer, its ability to modulate chemotherapy, radiotherapy and immunotherapy, and the possibility that the intestinal microbial is a new target for therapeutic approaches to improve the prognosis and quality of life of cancer patients.

Original languageEnglish
Pages (from-to)17915-17927
Number of pages13
JournalOncotarget
Volume9
Issue number25
DOIs
Publication statusPublished - Apr 1 2018

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Keywords

  • Cancer
  • Colon rectal cancer
  • Gut microbiota
  • Inflammation
  • Probiotics

ASJC Scopus subject areas

  • Oncology

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