TY - JOUR
T1 - Microbiota effects on cancer
T2 - From risks to therapies
AU - Rea, Domenica
AU - Coppola, Giovanni
AU - Palma, Giuseppe
AU - Barbieri, Antonio
AU - Luciano, Antonio
AU - Del Prete, Paola
AU - Rossetti, Sabrina
AU - Berretta, Massimiliano
AU - Facchini, Gaetano
AU - Perdonà, Sisto
AU - Turco, Maria Caterina
AU - Arra, Claudio
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Gut microbiota, a group of 1014 bacteria, eukaryotes and virus living in gastrointestinal tract, is crucial for many physiological processes in particular plays an important role in inflammatory and immune reactions. Several internal and external factors can influence this population, and shifts in their composition, have been demonstrated to contribute and affect different diseases. During dysbiosis several bacteria related to inflammation, one of the most necessary factors in carcinogenesis; it has been shown that some bacterial strains through deregulation of different signals/pathways may affect tumor development through the production of many factors. Gut microbiota might be considered as a holistic hub point for cancer development: direct and indirect involvements have been studying in several neoplasms such as colon rectal cancer, hepatocellular carcinoma and breast cancer. This review discuss over the evidence of crosstalk between gut microbiota and cancer, its ability to modulate chemotherapy, radiotherapy and immunotherapy, and the possibility that the intestinal microbial is a new target for therapeutic approaches to improve the prognosis and quality of life of cancer patients.
AB - Gut microbiota, a group of 1014 bacteria, eukaryotes and virus living in gastrointestinal tract, is crucial for many physiological processes in particular plays an important role in inflammatory and immune reactions. Several internal and external factors can influence this population, and shifts in their composition, have been demonstrated to contribute and affect different diseases. During dysbiosis several bacteria related to inflammation, one of the most necessary factors in carcinogenesis; it has been shown that some bacterial strains through deregulation of different signals/pathways may affect tumor development through the production of many factors. Gut microbiota might be considered as a holistic hub point for cancer development: direct and indirect involvements have been studying in several neoplasms such as colon rectal cancer, hepatocellular carcinoma and breast cancer. This review discuss over the evidence of crosstalk between gut microbiota and cancer, its ability to modulate chemotherapy, radiotherapy and immunotherapy, and the possibility that the intestinal microbial is a new target for therapeutic approaches to improve the prognosis and quality of life of cancer patients.
KW - Cancer
KW - Colon rectal cancer
KW - Gut microbiota
KW - Inflammation
KW - Probiotics
UR - http://www.scopus.com/inward/record.url?scp=85044824579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044824579&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.24681
DO - 10.18632/oncotarget.24681
M3 - Review article
AN - SCOPUS:85044824579
VL - 9
SP - 17915
EP - 17927
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 25
ER -