Microcirculation and oxidative stress

Etorre Crimi, L. J. Ignarro, C. Napoli

Research output: Contribution to journalArticle

Abstract

The microcirculation is a complex and integrated system, transporting oxygen and nutrients to the cells. The key component of this system is the endothelium, contributing to the local balance between pro and anti-inflammatory mediators, hemostatic balance, as well as vascular permeability and cell proliferation. A constant shear stress maintains vascular endothelium homeostasis while perturbed shear stress leads to changes in secretion of vasodilator and vasoconstrictor agents. Increased oxidative stress is a major pathogenetic mechanism of endothelial dysfunction by decreasing NO bioavailability, promoting inflammation and participating in activation of intracellular signals cascade, so influencing ion channels activation, signal transduction pathways, cytoskeleton remodelling, intercellular communication and ultimately gene expression. Targeting the microvascular inflammation and oxidative stress is a fascinating approach for novel therapies in order to decrease morbidity and mortality of chronic and acute diseases.

Original languageEnglish
Pages (from-to)1364-1375
Number of pages12
JournalFree Radical Research
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Antioxidants
  • Endothelial dysfunction
  • Microcirculation
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry

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