Microemulsion formulation of cyclosporine in pediatric liver transplantation

Daniele Alberti, Pierre Wallemacq, Diego Falchetti, Jean De Ville De Goyet, Waifro Rigamonti, Anna Panzali, Etienne Sokal, Jean Bernard Otte, Raymond Reding

Research output: Contribution to journalArticle

Abstract

The oral bioavailability of Sandimmun can be impaired by cholestasis, external biliary diversion, and diarrhea. We report two cases of pediatric liver transplant recipients who experienced chronic rejection and diarrhea secondary to proximal bowel resection. These conditions resulted in poor oral absorption of Sandimmun; the children were converted to the new oral microemulsion formulation Neoral, which significantly improved oral absorption, allowing intravenous cyclosporine weaning and patient discharge. Comparative pharmacokinetic studies were performed in both cases, and the relative Neoral/Sandimmun bioavailabilities were 32.9 and 5.4, respectively. Accordingly, Neoral may constitute a good alternative to ensure the effectiveness of oral cyclosporine administration, particularly in liver- transplanted children with severe cholestasis or shortened small bowel.

Original languageEnglish
Pages (from-to)512-514
Number of pages3
JournalTransplantation
Volume61
Issue number3
DOIs
Publication statusPublished - Feb 15 1996

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Fingerprint Dive into the research topics of 'Microemulsion formulation of cyclosporine in pediatric liver transplantation'. Together they form a unique fingerprint.

  • Cite this

    Alberti, D., Wallemacq, P., Falchetti, D., De Ville De Goyet, J., Rigamonti, W., Panzali, A., Sokal, E., Otte, J. B., & Reding, R. (1996). Microemulsion formulation of cyclosporine in pediatric liver transplantation. Transplantation, 61(3), 512-514. https://doi.org/10.1097/00007890-199602150-00035