Microenvironmental influences in chronic lymphocytic leukaemia: The role of antigen stimulation

P. Ghia, N. Chiorazzi, K. Stamatopoulos

Research output: Contribution to journalArticlepeer-review


Several studies suggest that immune-mediated pathways are important in the pathogenesis of chronic lymphocytic leukaemia (CLL). The in vivo accumulation of leukaemic lymphocytes is facilitated by interactions of CLL cells with other cells and soluble factors that probably occur more often within the microenvironment through classical receptor-ligand interactions. These include CD40L-CD40 and chemokine-chemokine receptor interactions as well as B cell receptor (BCR) engagement by (auto)antigens. Indeed, the categorizations of CLL patients based on immunoglobulin heavy variable (IGHV) gene mutations and structure of the clone's BCR suggest that CLL patient outcome could be a reflection of ongoing BCR signalling in the context of other co-signals.

Original languageEnglish
Pages (from-to)549-562
Number of pages14
JournalJournal of Internal Medicine
Issue number6
Publication statusPublished - Dec 2008


  • (auto)antigen
  • Anergy
  • Apoptosis
  • B cell receptor
  • CLL
  • Microenvironment

ASJC Scopus subject areas

  • Internal Medicine


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