Interazioni micro-ambientali e comportamento clinico in leucemia linfatica cronica: La lezione del CD49d

Translated title of the contribution: Microenvironmental interactions and clinical behaviour in chronic lymphocytic leukemia: The CD49d lesson

D. Benedetti, A. Zucchetto, P. Bulian, C. Tripodo, R. Bomben, M. Dal Bo, G. Del Poeta, F. M. Rossi, M. Degan, F. Tedesco, S. Deaglio, F. Malavasi, Valter Gattei

Research output: Contribution to journalArticle

Abstract

The results that will be presented take advantage of previous studies of gene expression and surface antigen expression profiles, identifying CD49d expression as a negative prognosticator for CLL patients, often in association with CD38 expression and an unmutated mutational status of IGHV genes, both negative prognostic markers in CLL. Altogether, the results that will be discussed contribute to define a model of interaction between CLL cells and the microenvironment. According to this model, CD38/CD49d-expressing CLL cells release two specific chemokines (CCL3 and CCL4) upon CD38 triggering by its natural counter-receptor CD31. CCL3 and CCL4 are eventually capable to recruit TNFα-producing macrophages, which in turn are responsible for VCAM-1 upregulation by stromal/endothelial cells. VCAM-1/CD49d interactions result in an increased survival of CD49d-expressing CLL cells. Some of the molecules involved in the afore-mentioned network could be of interest as putative therapeutic targets (e.g. CD49d). Given these preliminary results, the following discussion will focus on the CD38 and CD49d surface distribution in CLL cells, and in particular on their association in the context of specific signaling areas of cell membranes (raft domains). Finally, the functional meaning beyond this supramolecular complex will be discussed introducing results of adhesion assays performed with CD49d engagement by VCAM-1 on CLL cells.

Original languageItalian
Pages (from-to)70-73
Number of pages4
JournalRivista Italiana della Medicina di Laboratorio
Volume6
Issue number3 SUPPL. 1
Publication statusPublished - 2010

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, medical
  • Medical Laboratory Technology

Cite this

Benedetti, D., Zucchetto, A., Bulian, P., Tripodo, C., Bomben, R., Dal Bo, M., Del Poeta, G., Rossi, F. M., Degan, M., Tedesco, F., Deaglio, S., Malavasi, F., & Gattei, V. (2010). Interazioni micro-ambientali e comportamento clinico in leucemia linfatica cronica: La lezione del CD49d. Rivista Italiana della Medicina di Laboratorio, 6(3 SUPPL. 1), 70-73.