Microenvironmental Interactions in Chronic Lymphocytic Leukemia: The Master Role of CD49d

Michele Dal Bo, Erika Tissino, Dania Benedetti, Chiara Caldana, Riccardo Bomben, Giovanni Del Poeta, Gianluca Gaidano, Francesca Maria Rossi, Antonella Zucchetto, Valter Gattei

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation/expansion of a clonal population of neoplastic cells with the morphologic appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A combination of genetic lesions is primarily responsible for the first step(s) of neoplastic transformation, along with microenvironmental signals, which concurrently operate by enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a pivotal role in mediating both cell-cell and cell-matrix interactions in CLL-involved tissues, eventually delivering pro-survival signals and protecting CLL cells from drug-induced damages. In the present review, we address, in detail, CD49d activities in the CLL microenvironment, CD49d functional and physical interactions with other microenvironmental receptors (including CD38 and B-cell receptor), and the relationship of CD49d expression with specific cytogenetic features in CLL.

Original languageEnglish
Pages (from-to)168-176
Number of pages9
JournalSeminars in Hematology
Volume51
Issue number3
DOIs
Publication statusPublished - 2014

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B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Cytogenetics
Cell Communication
Bone Marrow
Apoptosis
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Microenvironmental Interactions in Chronic Lymphocytic Leukemia : The Master Role of CD49d. / Dal Bo, Michele; Tissino, Erika; Benedetti, Dania; Caldana, Chiara; Bomben, Riccardo; Del Poeta, Giovanni; Gaidano, Gianluca; Rossi, Francesca Maria; Zucchetto, Antonella; Gattei, Valter.

In: Seminars in Hematology, Vol. 51, No. 3, 2014, p. 168-176.

Research output: Contribution to journalArticle

Dal Bo, M, Tissino, E, Benedetti, D, Caldana, C, Bomben, R, Del Poeta, G, Gaidano, G, Rossi, FM, Zucchetto, A & Gattei, V 2014, 'Microenvironmental Interactions in Chronic Lymphocytic Leukemia: The Master Role of CD49d', Seminars in Hematology, vol. 51, no. 3, pp. 168-176. https://doi.org/10.1053/j.seminhematol.2014.05.002
Dal Bo, Michele ; Tissino, Erika ; Benedetti, Dania ; Caldana, Chiara ; Bomben, Riccardo ; Del Poeta, Giovanni ; Gaidano, Gianluca ; Rossi, Francesca Maria ; Zucchetto, Antonella ; Gattei, Valter. / Microenvironmental Interactions in Chronic Lymphocytic Leukemia : The Master Role of CD49d. In: Seminars in Hematology. 2014 ; Vol. 51, No. 3. pp. 168-176.
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