Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence

G. Cutrona, C. Tripodo, S. Matis, A.G. Recchia, C. Massucco, M. Fabbi, M. Colombo, L. Emionite, S. Sangaletti, A. Gulino, D. Reverberi, R. Massara, S. Boccardo, D. De Totero, S. Salvi, M. Cilli, M. Pellicanò, M. Manzoni, S. Fabris, I. AiroldiF. Valdora, S. Ferrini, M. Gentile, E. Vigna, S. Bossio, L. De Stefano, A. Palummo, G. Iaquinta, M. Cardillo, S. Zupo, G. Cerruti, A. Ibatici, A. Neri, F. Fais, M. Ferrarini, F. Morabito

Research output: Contribution to journalArticle

Original languageEnglish
JournalScience Translational Medicine
Volume10
Issue number428
DOIs
Publication statusPublished - 2018

Keywords

  • CD40 ligand
  • interleukin 12 receptor beta1
  • interleukin 23
  • interleukin 23 receptor
  • interleukin 23p19
  • monoclonal antibody
  • animal experiment
  • animal model
  • animal tissue
  • Article
  • autocrine effect
  • cell proliferation
  • chronic lymphatic leukemia
  • coculture
  • controlled study
  • cytokine production
  • cytokine release
  • human
  • human tissue
  • leukemia cell
  • lymphoid tissue
  • major clinical study
  • mouse
  • nonhuman
  • paracrine signaling
  • priority journal
  • stroma cell
  • T lymphocyte
  • time to treatment
  • tumor microenvironment
  • upregulation

Cite this

Cutrona, G., Tripodo, C., Matis, S., Recchia, A. G., Massucco, C., Fabbi, M., Colombo, M., Emionite, L., Sangaletti, S., Gulino, A., Reverberi, D., Massara, R., Boccardo, S., De Totero, D., Salvi, S., Cilli, M., Pellicanò, M., Manzoni, M., Fabris, S., ... Morabito, F. (2018). Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence. Science Translational Medicine, 10(428). https://doi.org/10.1126/scitranslmed.aal1571