Microfabricated fractal trees as scaffolds for capillary morphogenesis: Applications in therapeutic angiogenesis and vascular tissue engineering

G. Ciaravella, G. Vozzi, F. Bianchi, M. Rosi, C. Costanza, P. Madeddu, A. Ahluwalia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

New engineering and biological techniques are combined to realize constructs for substitution of damaged or diseased tissue. In particular, we combine fractal algorithms and rapid prototyping microfabrication methods to generate polymer scaffolds which simulate branching capillary networks. Human endothelial cells seeded on the scaffolds are then induced to angiogenesis through transfuction with adenovirus vectors carrying the gene for human kallikrein. The constructs have potential applications in vascular tissue engineering and therapeutic angiogenesis.

Original languageEnglish
Title of host publicationProceedings of the IEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering, MCTE 2002
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages46-47
Number of pages2
ISBN (Print)0780375572, 9780780375574
DOIs
Publication statusPublished - 2002
EventIEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering, MCTE 2002 - Genoa, Italy
Duration: Jun 6 2002Jun 9 2002

Other

OtherIEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering, MCTE 2002
Country/TerritoryItaly
CityGenoa
Period6/6/026/9/02

Keywords

  • Capillary
  • Microfabrication
  • Therapeutic angiogenesis
  • Tissue engineering

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Biotechnology

Fingerprint

Dive into the research topics of 'Microfabricated fractal trees as scaffolds for capillary morphogenesis: Applications in therapeutic angiogenesis and vascular tissue engineering'. Together they form a unique fingerprint.

Cite this