Microfluidic Synthesis of Hybrid TiO2-Anisotropic Gold Nanoparticles with Visible and Near-Infrared Activity

Marcello Marelli, Filippo Bossola, Gaia Spinetti, Elena Sangalli, Vladimiro Dal Santo, Rinaldo Psaro, Laura Polito

Research output: Contribution to journalArticlepeer-review


Anisotropic gold nanoparticles (AuNPs), with their unique physical and optical properties, are emerging as smart and key nanomaterials and are being exploited in many crucial fields. To further improve their range of action, anisotropic AuNPs have been coupled with semiconductors, mainly TiO2 (titania), receiving great interest as powerful platforms both in biomedicine and in catalytic applications. Such hybrid nanoparticles show new properties that arise from the synergic action of the components and rely on NP size, morphology, and arrangement. Therefore, continuous advances in design and fabrication of new hybrid titania@gold NPs (TiO2@AuNPs) are urgent and highly desirable. Here, we propose an effective protocol to produce multibranched AuNPs covered by a controlled TiO2 thin layer, exploiting a one-pot microfluidic process. The proposed method allows the in-flow and reliable synthesis of titania-functionalized-anisotropic gold nanoparticles by avoiding the use of toxic surfactants and controlling the titania shell formation. TiO2@AuNPs have been fully characterized in terms of morphology, stability, and biocompatibility, and their activity in photocatalysis has been tested and verified.

Original languageEnglish
Pages (from-to)38522-38529
Number of pages8
JournalACS Applied Materials and Interfaces
Issue number34
Publication statusPublished - Aug 26 2020


  • anisotropy
  • fluidic synthesis
  • gold nanoparticles
  • hybrid nanoparticles
  • photocatalysis
  • titania

ASJC Scopus subject areas

  • Materials Science(all)


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