Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells

Oleg Butovsky, Yaniv Ziv, Adi Schwartz, Gennady Landa, Adolfo E. Talpalar, Stefano Pluchino, Gianvito Martino, Michal Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Cell renewal in the adult central nervous system (CNS) is limited, and is blocked in inflammatory brain conditions. We show that both neurogenesis and oligodendrogenesis of adult neural progenitor cells in mice are blocked by inflammation-associated (endotoxin-activated) microglia, but induced by microglia activated by cytokines (IL-4 or low level of IFN-γ) associated with T-helper cells. Blockage was correlated with up-regulation of microglial production of tumor necrosis factor-α. The effect induced by IL-4-activated microglia was mediated, at least in part, by insulin-like growth factor-I. The IL-4-activated microglia showed a bias towards oligodendrogenesis whereas the IFN-γ-activated microglia showed a bias towards neurogenesis. It thus appears that microglial phenotype critically affects their ability to support or impair cell renewal from adult stem cell.

Original languageEnglish
Pages (from-to)149-160
Number of pages12
JournalMolecular and Cellular Neuroscience
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Fingerprint Dive into the research topics of 'Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells'. Together they form a unique fingerprint.

Cite this