TY - JOUR
T1 - Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
AU - Butovsky, Oleg
AU - Ziv, Yaniv
AU - Schwartz, Adi
AU - Landa, Gennady
AU - Talpalar, Adolfo E.
AU - Pluchino, Stefano
AU - Martino, Gianvito
AU - Schwartz, Michal
PY - 2006/1
Y1 - 2006/1
N2 - Cell renewal in the adult central nervous system (CNS) is limited, and is blocked in inflammatory brain conditions. We show that both neurogenesis and oligodendrogenesis of adult neural progenitor cells in mice are blocked by inflammation-associated (endotoxin-activated) microglia, but induced by microglia activated by cytokines (IL-4 or low level of IFN-γ) associated with T-helper cells. Blockage was correlated with up-regulation of microglial production of tumor necrosis factor-α. The effect induced by IL-4-activated microglia was mediated, at least in part, by insulin-like growth factor-I. The IL-4-activated microglia showed a bias towards oligodendrogenesis whereas the IFN-γ-activated microglia showed a bias towards neurogenesis. It thus appears that microglial phenotype critically affects their ability to support or impair cell renewal from adult stem cell.
AB - Cell renewal in the adult central nervous system (CNS) is limited, and is blocked in inflammatory brain conditions. We show that both neurogenesis and oligodendrogenesis of adult neural progenitor cells in mice are blocked by inflammation-associated (endotoxin-activated) microglia, but induced by microglia activated by cytokines (IL-4 or low level of IFN-γ) associated with T-helper cells. Blockage was correlated with up-regulation of microglial production of tumor necrosis factor-α. The effect induced by IL-4-activated microglia was mediated, at least in part, by insulin-like growth factor-I. The IL-4-activated microglia showed a bias towards oligodendrogenesis whereas the IFN-γ-activated microglia showed a bias towards neurogenesis. It thus appears that microglial phenotype critically affects their ability to support or impair cell renewal from adult stem cell.
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U2 - 10.1016/j.mcn.2005.10.006
DO - 10.1016/j.mcn.2005.10.006
M3 - Article
C2 - 16297637
AN - SCOPUS:30044434850
VL - 31
SP - 149
EP - 160
JO - Molecular and Cellular Neurosciences
JF - Molecular and Cellular Neurosciences
SN - 1044-7431
IS - 1
ER -