TY - JOUR
T1 - Micronutrient Deficiencies. An Unmet Need in Heart Failure
AU - Soukoulis, Victor
AU - Dihu, Jamil B.
AU - Sole, Michael
AU - Anker, Stefan D.
AU - Cleland, John
AU - Fonarow, Gregg C.
AU - Metra, Marco
AU - Pasini, Evasio
AU - Strzelczyk, Theresa
AU - Taegtmeyer, Heinrich
AU - Gheorghiade, Mihai
PY - 2009/10/27
Y1 - 2009/10/27
N2 - Heart failure (HF) is a common, disabling, and costly disease. Despite major advances in medical therapy, morbidity and mortality remain high, in part because current pharmacological regimens may not fully address some unique requirements of the heart for energy. The heart requires a continuous supply of energy-providing substrates and amino acids in order to maintain its function. In HF, defects in substrate metabolism and cardiac energy and substrate utilization may contribute to contractile dysfunction. HF is often accompanied by a deficiency in key micronutrients required for unimpeded energy transfer. Correcting these deficits has been proposed as a method to limit or even reverse the progressive myocyte dysfunction and/or necrosis in HF. This review summarizes the existing HF literature with respect to supplementation trials of key micronutrients involved in cardiac metabolism: coenzyme Q10, l-carnitine, thiamine, and amino acids, including taurine. Studies using a broader approach to supplementation are also considered. Although some of the results are promising, none are conclusive. There is a need for a prospective trial to examine the effects of micronutrient supplementation on morbidity and mortality in patients with HF.
AB - Heart failure (HF) is a common, disabling, and costly disease. Despite major advances in medical therapy, morbidity and mortality remain high, in part because current pharmacological regimens may not fully address some unique requirements of the heart for energy. The heart requires a continuous supply of energy-providing substrates and amino acids in order to maintain its function. In HF, defects in substrate metabolism and cardiac energy and substrate utilization may contribute to contractile dysfunction. HF is often accompanied by a deficiency in key micronutrients required for unimpeded energy transfer. Correcting these deficits has been proposed as a method to limit or even reverse the progressive myocyte dysfunction and/or necrosis in HF. This review summarizes the existing HF literature with respect to supplementation trials of key micronutrients involved in cardiac metabolism: coenzyme Q10, l-carnitine, thiamine, and amino acids, including taurine. Studies using a broader approach to supplementation are also considered. Although some of the results are promising, none are conclusive. There is a need for a prospective trial to examine the effects of micronutrient supplementation on morbidity and mortality in patients with HF.
KW - energy
KW - heart failure
KW - metabolism
KW - micronutrients
KW - nutrition
UR - http://www.scopus.com/inward/record.url?scp=70350020285&partnerID=8YFLogxK
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U2 - 10.1016/j.jacc.2009.08.012
DO - 10.1016/j.jacc.2009.08.012
M3 - Article
C2 - 19850206
AN - SCOPUS:70350020285
VL - 54
SP - 1660
EP - 1673
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 18
ER -