Micronutrients and laryngeal cancer risk in Italy and Switzerland: A case-control study

Ettore Bidoli, Cristina Bosetti, Carlo La Vecchia, Fabio Levi, Maria Parpinel, Renato Talamini, Eva Negri, Luigino Dal Maso, Silvia Franceschi

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Abstract

Objective: To investigate the relation between various micronutrients and laryngeal cancer risk. Methods: A case-control study was conducted in Italy and Switzerland between 1992 and 2000. Cases were 527 patients with incident cancer of larynx, admitted to the major teaching and general hospitals of the study areas. Controls were 1297 subjects admitted for acute, non-neoplastic diseases to the same network of hospitals. Dietary habits were assessed using a validated food-frequency questionnaire. Odds ratios (OR) and their corresponding 95% confidence intervals (CI) were computed using multiple logistic regression. Results: Significant inverse relations emerged between laryngeal cancer risk and intake of vitamin C (OR = 0.2, for the highest versus the lowest intake quintile; 95% CI: 0.2-0.4), β-carotene (OR = 0.2; 95% CI: 0.2-0.4), α-carotene (OR = 0.3; 95% CI: 0.2-0.5), lutein/zeaxanthin (OR = 0.4; 95% CI: 0.3-0.6), vitamin E (OR = 0.4; 95% CI: 0.3-0.6), β-criptoxanthin (OR = 0.4; 95% CI: 0.2-0.5), folic acid (OR = 0.4; 95% CI: 0.2-0.6), thiamin (OR = 0.4; 95% CI: 0.3-0.6), glutathione (OR = 0.5; 95% CI: 0.4-0.8), reduced glutathione (OR = 0.6; 95% CI: 0.4-0.8), vitamin B6 (OR = 0. 6; 95% CI: 0.4-0.9) and potassium (OR = 0.6; 95% CI: 0.4-0.9). Direct associations were found with zinc (OR = 1.5; 95% CI: 1.0-2.2) and vitamin D (OR = 1.8; 95% CI: 1.2-2.6). Combining low intakes of vitamin C, carotene, vitamin E, and folate with heavy smoking and drinking led to ORs between 80 and 170. Conclusions: This study provides further support that, independently from smoking and alcohol consumption, the intake of several micronutrients, including selected antioxidants, is inversely related to laryngeal cancer risk.

Original languageEnglish
Pages (from-to)477-484
Number of pages8
JournalCancer Causes and Control
Volume14
Issue number5
DOIs
Publication statusPublished - Jun 2003

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Laryngeal Neoplasms
Micronutrients
Switzerland
Italy
Case-Control Studies
Odds Ratio
Confidence Intervals
Carotenoids
Vitamin E
Folic Acid
Ascorbic Acid
Glutathione
Smoking
Lutein
Vitamin B 6
Thiamine
Feeding Behavior
Vitamin D
Teaching Hospitals
General Hospitals

Keywords

  • Case-control study
  • Diet
  • Laryngeal cancer
  • Micronutrients

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Micronutrients and laryngeal cancer risk in Italy and Switzerland : A case-control study. / Bidoli, Ettore; Bosetti, Cristina; La Vecchia, Carlo; Levi, Fabio; Parpinel, Maria; Talamini, Renato; Negri, Eva; Dal Maso, Luigino; Franceschi, Silvia.

In: Cancer Causes and Control, Vol. 14, No. 5, 06.2003, p. 477-484.

Research output: Contribution to journalArticle

Bidoli, Ettore ; Bosetti, Cristina ; La Vecchia, Carlo ; Levi, Fabio ; Parpinel, Maria ; Talamini, Renato ; Negri, Eva ; Dal Maso, Luigino ; Franceschi, Silvia. / Micronutrients and laryngeal cancer risk in Italy and Switzerland : A case-control study. In: Cancer Causes and Control. 2003 ; Vol. 14, No. 5. pp. 477-484.
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abstract = "Objective: To investigate the relation between various micronutrients and laryngeal cancer risk. Methods: A case-control study was conducted in Italy and Switzerland between 1992 and 2000. Cases were 527 patients with incident cancer of larynx, admitted to the major teaching and general hospitals of the study areas. Controls were 1297 subjects admitted for acute, non-neoplastic diseases to the same network of hospitals. Dietary habits were assessed using a validated food-frequency questionnaire. Odds ratios (OR) and their corresponding 95{\%} confidence intervals (CI) were computed using multiple logistic regression. Results: Significant inverse relations emerged between laryngeal cancer risk and intake of vitamin C (OR = 0.2, for the highest versus the lowest intake quintile; 95{\%} CI: 0.2-0.4), β-carotene (OR = 0.2; 95{\%} CI: 0.2-0.4), α-carotene (OR = 0.3; 95{\%} CI: 0.2-0.5), lutein/zeaxanthin (OR = 0.4; 95{\%} CI: 0.3-0.6), vitamin E (OR = 0.4; 95{\%} CI: 0.3-0.6), β-criptoxanthin (OR = 0.4; 95{\%} CI: 0.2-0.5), folic acid (OR = 0.4; 95{\%} CI: 0.2-0.6), thiamin (OR = 0.4; 95{\%} CI: 0.3-0.6), glutathione (OR = 0.5; 95{\%} CI: 0.4-0.8), reduced glutathione (OR = 0.6; 95{\%} CI: 0.4-0.8), vitamin B6 (OR = 0. 6; 95{\%} CI: 0.4-0.9) and potassium (OR = 0.6; 95{\%} CI: 0.4-0.9). Direct associations were found with zinc (OR = 1.5; 95{\%} CI: 1.0-2.2) and vitamin D (OR = 1.8; 95{\%} CI: 1.2-2.6). Combining low intakes of vitamin C, carotene, vitamin E, and folate with heavy smoking and drinking led to ORs between 80 and 170. Conclusions: This study provides further support that, independently from smoking and alcohol consumption, the intake of several micronutrients, including selected antioxidants, is inversely related to laryngeal cancer risk.",
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AU - Bosetti, Cristina

AU - La Vecchia, Carlo

AU - Levi, Fabio

AU - Parpinel, Maria

AU - Talamini, Renato

AU - Negri, Eva

AU - Dal Maso, Luigino

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N2 - Objective: To investigate the relation between various micronutrients and laryngeal cancer risk. Methods: A case-control study was conducted in Italy and Switzerland between 1992 and 2000. Cases were 527 patients with incident cancer of larynx, admitted to the major teaching and general hospitals of the study areas. Controls were 1297 subjects admitted for acute, non-neoplastic diseases to the same network of hospitals. Dietary habits were assessed using a validated food-frequency questionnaire. Odds ratios (OR) and their corresponding 95% confidence intervals (CI) were computed using multiple logistic regression. Results: Significant inverse relations emerged between laryngeal cancer risk and intake of vitamin C (OR = 0.2, for the highest versus the lowest intake quintile; 95% CI: 0.2-0.4), β-carotene (OR = 0.2; 95% CI: 0.2-0.4), α-carotene (OR = 0.3; 95% CI: 0.2-0.5), lutein/zeaxanthin (OR = 0.4; 95% CI: 0.3-0.6), vitamin E (OR = 0.4; 95% CI: 0.3-0.6), β-criptoxanthin (OR = 0.4; 95% CI: 0.2-0.5), folic acid (OR = 0.4; 95% CI: 0.2-0.6), thiamin (OR = 0.4; 95% CI: 0.3-0.6), glutathione (OR = 0.5; 95% CI: 0.4-0.8), reduced glutathione (OR = 0.6; 95% CI: 0.4-0.8), vitamin B6 (OR = 0. 6; 95% CI: 0.4-0.9) and potassium (OR = 0.6; 95% CI: 0.4-0.9). Direct associations were found with zinc (OR = 1.5; 95% CI: 1.0-2.2) and vitamin D (OR = 1.8; 95% CI: 1.2-2.6). Combining low intakes of vitamin C, carotene, vitamin E, and folate with heavy smoking and drinking led to ORs between 80 and 170. Conclusions: This study provides further support that, independently from smoking and alcohol consumption, the intake of several micronutrients, including selected antioxidants, is inversely related to laryngeal cancer risk.

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