Micronutrients involved in one-carbon metabolism and risk of breast cancer subtypes

Ilaria Cancarini; Vittorio Krogh; Claudia Agnoli; Sara Grioni; Giuseppe Matullo; Valeria Pala; Samuele Pedraglio; Paolo Contiero; Cristina Riva; Paola Muti; Sabina Sieri

doi:10.1371/journal.pone.0138318

Micronutrients involved in one-carbon metabolism and risk of breast cancer subtypes

Ilaria Cancarini, Vittorio Krogh, Claudia Agnoli, Sara Grioni, Giuseppe Matullo, Valeria Pala, Samuele Pedraglio, Paolo Contiero, Cristina Riva, Paola Muti, Sabina Sieri

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Background Vitamins involved in one-carbon metabolism are hypothesized to influence breast cancer (BC) risk. However, epidemiologic studies that examined associations between B vitamin intake and BC risk have provided inconsistent results. We prospectively examined, in the Italian ORDET cohort, whether B vitamin consumption was associated with risk of BC and BC subtypes. Methods After a mean follow-up of 16.5 years, 391 BCs were diagnosed among 10,786 cohort women. B vitamin intakes were estimated from food frequency questionnaires. Cox proportional hazard models adjusted for energy intake and confounders, estimated hazard ratios (HR) with 95% confidence intervals (CIs) for BC according to intake. Results RRs were 0.61 (95% CI 0.38-0.97 highest vs. lowest quartile; P trend 0.025) for thiamine; 0.48 (95% CI 0.32-0.71; P trend

Original language	English
Article number	e0138318
Journal	PLoS One
Volume	10
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0138318
Publication status	Published - Sep 16 2015

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Micronutrients involved in one-carbon metabolism and risk of breast cancer subtypes. / Cancarini, Ilaria; Krogh, Vittorio ; Agnoli, Claudia ; Grioni, Sara; Matullo, Giuseppe; Pala, Valeria; Pedraglio, Samuele; Contiero, Paolo; Riva, Cristina; Muti, Paola; Sieri, Sabina.

In: PLoS One, Vol. 10, No. 9, e0138318, 16.09.2015.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background Vitamins involved in one-carbon metabolism are hypothesized to influence breast cancer (BC) risk. However, epidemiologic studies that examined associations between B vitamin intake and BC risk have provided inconsistent results. We prospectively examined, in the Italian ORDET cohort, whether B vitamin consumption was associated with risk of BC and BC subtypes. Methods After a mean follow-up of 16.5 years, 391 BCs were diagnosed among 10,786 cohort women. B vitamin intakes were estimated from food frequency questionnaires. Cox proportional hazard models adjusted for energy intake and confounders, estimated hazard ratios (HR) with 95% confidence intervals (CIs) for BC according to intake. Results RRs were 0.61 (95% CI 0.38-0.97 highest vs. lowest quartile; P trend 0.025) for thiamine; 0.48 (95% CI 0.32-0.71; P trend ",

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AU - Cancarini, Ilaria

AU - Krogh, Vittorio

AU - Agnoli, Claudia

AU - Grioni, Sara

AU - Matullo, Giuseppe

AU - Pala, Valeria

AU - Pedraglio, Samuele

AU - Contiero, Paolo

AU - Riva, Cristina

AU - Muti, Paola

AU - Sieri, Sabina

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