Micronutrients involved in one-carbon metabolism and risk of breast cancer subtypes

Ilaria Cancarini, Vittorio Krogh, Claudia Agnoli, Sara Grioni, Giuseppe Matullo, Valeria Pala, Samuele Pedraglio, Paolo Contiero, Cristina Riva, Paola Muti, Sabina Sieri

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Background Vitamins involved in one-carbon metabolism are hypothesized to influence breast cancer (BC) risk. However, epidemiologic studies that examined associations between B vitamin intake and BC risk have provided inconsistent results. We prospectively examined, in the Italian ORDET cohort, whether B vitamin consumption was associated with risk of BC and BC subtypes. Methods After a mean follow-up of 16.5 years, 391 BCs were diagnosed among 10,786 cohort women. B vitamin intakes were estimated from food frequency questionnaires. Cox proportional hazard models adjusted for energy intake and confounders, estimated hazard ratios (HR) with 95% confidence intervals (CIs) for BC according to intake. Results RRs were 0.61 (95% CI 0.38-0.97 highest vs. lowest quartile; P trend 0.025) for thiamine; 0.48 (95% CI 0.32-0.71; P trend

Original languageEnglish
Article numbere0138318
JournalPLoS One
Issue number9
Publication statusPublished - Sep 16 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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