Micropapillary bladder cancer metastatic to the breast: A case report and brief literature review

Elena Lievore, Letterio Runza, Michele Ghidini, Barbara Galassi, Andrea Gallioli, Carolina Bebi, Luca Boeri, Concetta Blundo, Claudia Francesca Rossi, Fabrizio Longo, Giancarlo Albo, Emanuele Montanari, Elisa De Lorenzis

Research output: Contribution to journalArticlepeer-review


Background: Bladder cancer (BC) usually metastasizes to the lymph nodes, bone, lung, liver and peritoneum, but rarely in the breast. Case Report: We present a case of a 66-year-old female diagnosed with a massive bladder tumor, who presented a right mammary nodule after neo-adjuvant chemotherapy. A biopsy of the nodule did not permit a definite diagnosis of metastatic spread, which was confirmed by excision of the nodule. In the literature, we found only 7 other similar cases of BC metastasis to the breast. Currently, a non-invasive method for differentiating a breast metastasis from primary cancer is lacking, although there are some clinical and radiological aspects that may help the diagnosis. Histological examination provides diagnostic certainty. Conclusion: Breast metastases from BC are unusual and consequently difficult to identify without non-invasive tools. Clinical history and histological study play a pivotal role in determining the correct diagnosis.

Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalIn Vivo
Issue number1
Publication statusPublished - Jan 2021


  • Breast cancer
  • Immunotherapy
  • Metastasis
  • Neoadjuvant therapy
  • Urothelial cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology


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