MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-cell precursor acute lymphoblastic leukemia

Elisa Tassano, Maura Acquila, Elisa Tavella, Concetta Micalizzi, Claudio Panarello, Cristina Morerio

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosomal translocations involving the immunoglobulin heavy chain (IGH) locus are common abnormalities in mature B-cell neoplasms. Recent findings have also revealed their significant role in B-cell precursor acute lymphoblastic leukemia. As a rule, IGH translocations generate transcriptional activation of the oncogene localized in the proximity of the breakpoint. In this study, we describe a pediatric case of B-cell precursor acute lymphoblastic leukemia showing microRNA-125b-1 (MIR125B1) and BLID gene overexpression, resulting from a novel t(11;14)(q24.1;q32) translocation involving IGH. This is the first report describing the upregulation of a microRNA due to its juxtaposition to protein-coding gene regulatory elements and the overexpression of two neighboring genes as a consequence of transcriptional enhancers localized in the vicinity of the IGH gene.

Original languageEnglish
Pages (from-to)682-687
Number of pages6
JournalGenes Chromosomes and Cancer
Volume49
Issue number8
DOIs
Publication statusPublished - Aug 2010

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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