MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis

Stefano Alivernini; Elisa Gremese; Charles McSharry; Barbara Tolusso; Gianfranco Ferraccioli; Iain B. McInnes; Mariola Kurowska-Stolarska

doi:10.3389/fimmu.2017.01932

MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis

Stefano Alivernini, Elisa Gremese, Charles McSharry, Barbara Tolusso, Gianfranco Ferraccioli, Iain B. McInnes, Mariola Kurowska-Stolarska

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Review article › peer-review

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

Original language	English
Article number	1932
Journal	Frontiers in Immunology
Volume	8
Issue number	JAN
DOIs	https://doi.org/10.3389/fimmu.2017.01932
Publication status	Published - Jan 5 2018

Keywords

Antibody production
Arthritis rheumatoid
Autoimmunity
Inflammation
MicroRNA-155

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.3389/fimmu.2017.01932

Fingerprint Dive into the research topics of 'MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis'. Together they form a unique fingerprint.

Cite this

MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis. / Alivernini, Stefano; Gremese, Elisa; McSharry, Charles; Tolusso, Barbara; Ferraccioli, Gianfranco; McInnes, Iain B.; Kurowska-Stolarska, Mariola.

In: Frontiers in Immunology, Vol. 8, No. JAN, 1932, 05.01.2018.

Research output: Contribution to journal › Review article › peer-review

@article{7d54be4a7ee94780b776aac427e2e690,

title = "MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis",

abstract = "MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.",

keywords = "Antibody production, Arthritis rheumatoid, Autoimmunity, Inflammation, MicroRNA-155",

author = "Stefano Alivernini and Elisa Gremese and Charles McSharry and Barbara Tolusso and Gianfranco Ferraccioli and McInnes, {Iain B.} and Mariola Kurowska-Stolarska",

year = "2018",

month = jan,

day = "5",

doi = "10.3389/fimmu.2017.01932",

language = "English",

volume = "8",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media S.A.",

number = "JAN",

}

TY - JOUR

T1 - MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis

AU - Alivernini, Stefano

AU - Gremese, Elisa

AU - McSharry, Charles

AU - Tolusso, Barbara

AU - Ferraccioli, Gianfranco

AU - McInnes, Iain B.

AU - Kurowska-Stolarska, Mariola

PY - 2018/1/5

Y1 - 2018/1/5

N2 - MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

AB - MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

KW - Antibody production

KW - Arthritis rheumatoid

KW - Autoimmunity

KW - Inflammation

KW - MicroRNA-155

UR - http://www.scopus.com/inward/record.url?scp=85040101308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040101308&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2017.01932

DO - 10.3389/fimmu.2017.01932

M3 - Review article

AN - SCOPUS:85040101308

VL - 8

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - JAN

M1 - 1932

ER -