Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
| Original language | English |
|---|---|
| Article number | 1932 |
| Journal | Frontiers in Immunology |
| Volume | 8 |
| Issue number | JAN |
| DOIs | |
| Publication status | Published - Jan 5 2018 |
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Keywords
- Antibody production
- Arthritis rheumatoid
- Autoimmunity
- Inflammation
- MicroRNA-155
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis. / Alivernini, Stefano; Gremese, Elisa; McSharry, Charles; Tolusso, Barbara; Ferraccioli, Gianfranco; McInnes, Iain B.; Kurowska-Stolarska, Mariola.
In: Frontiers in Immunology, Vol. 8, No. JAN, 1932, 05.01.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis
AU - Alivernini, Stefano
AU - Gremese, Elisa
AU - McSharry, Charles
AU - Tolusso, Barbara
AU - Ferraccioli, Gianfranco
AU - McInnes, Iain B.
AU - Kurowska-Stolarska, Mariola
PY - 2018/1/5
Y1 - 2018/1/5
N2 - MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
AB - MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
KW - Antibody production
KW - Arthritis rheumatoid
KW - Autoimmunity
KW - Inflammation
KW - MicroRNA-155
UR - http://www.scopus.com/inward/record.url?scp=85040101308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040101308&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2017.01932
DO - 10.3389/fimmu.2017.01932
M3 - Review article
AN - SCOPUS:85040101308
VL - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - JAN
M1 - 1932
ER -