MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis

Stefano Alivernini, Elisa Gremese, Charles McSharry, Barbara Tolusso, Gianfranco Ferraccioli, Iain B. McInnes, Mariola Kurowska-Stolarska

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

Original languageEnglish
Article number1932
JournalFrontiers in Immunology
Volume8
Issue numberJAN
DOIs
Publication statusPublished - Jan 5 2018

Keywords

  • Antibody production
  • Arthritis rheumatoid
  • Autoimmunity
  • Inflammation
  • MicroRNA-155

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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