MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis

Stefano Alivernini, Elisa Gremese, Charles McSharry, Barbara Tolusso, Gianfranco Ferraccioli, Iain B. McInnes, Mariola Kurowska-Stolarska

Research output: Contribution to journalReview article

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

Original languageEnglish
Article number1932
JournalFrontiers in Immunology
Volume8
Issue numberJAN
DOIs
Publication statusPublished - Jan 5 2018

Fingerprint

Adaptive Immunity
MicroRNAs
Innate Immunity
Arthritis
Immune System
Small Untranslated RNA
Autoimmunity
Transcriptome
Rheumatoid Arthritis
Fibrosis
Biomarkers
Inflammation
Neoplasms
Therapeutics

Keywords

  • Antibody production
  • Arthritis rheumatoid
  • Autoimmunity
  • Inflammation
  • MicroRNA-155

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I. B., & Kurowska-Stolarska, M. (2018). MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology, 8(JAN), [1932]. https://doi.org/10.3389/fimmu.2017.01932

MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis. / Alivernini, Stefano; Gremese, Elisa; McSharry, Charles; Tolusso, Barbara; Ferraccioli, Gianfranco; McInnes, Iain B.; Kurowska-Stolarska, Mariola.

In: Frontiers in Immunology, Vol. 8, No. JAN, 1932, 05.01.2018.

Research output: Contribution to journalReview article

Alivernini, S, Gremese, E, McSharry, C, Tolusso, B, Ferraccioli, G, McInnes, IB & Kurowska-Stolarska, M 2018, 'MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis', Frontiers in Immunology, vol. 8, no. JAN, 1932. https://doi.org/10.3389/fimmu.2017.01932
Alivernini, Stefano ; Gremese, Elisa ; McSharry, Charles ; Tolusso, Barbara ; Ferraccioli, Gianfranco ; McInnes, Iain B. ; Kurowska-Stolarska, Mariola. / MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis. In: Frontiers in Immunology. 2018 ; Vol. 8, No. JAN.
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