MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity

F Capitano, J Camon, V. Licursi, V Ferretti, L Maggi, Maria Scianni, G. Del Vecchio, A Rinaldi, C. Mannironi, C Limatola, C. Presutti, A. Mele

Research output: Contribution to journalArticle

Abstract

MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalNeurobiology of Learning and Memory
Volume139
Early online dateDec 27 2016
DOIs
Publication statusPublished - Mar 2017

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Neuronal Plasticity
MicroRNAs
Untranslated RNA
Long-Term Memory
Long-Term Potentiation
Gene Expression Regulation
Down-Regulation
Brain
Spatial Learning
Spatial Memory

Keywords

  • Journal Article

Cite this

MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity. / Capitano, F; Camon, J; Licursi, V.; Ferretti, V; Maggi, L; Scianni, Maria; Del Vecchio, G.; Rinaldi, A; Mannironi, C.; Limatola, C; Presutti, C.; Mele, A.

In: Neurobiology of Learning and Memory, Vol. 139, 03.2017, p. 63-68.

Research output: Contribution to journalArticle

Capitano, F, Camon, J, Licursi, V, Ferretti, V, Maggi, L, Scianni, M, Del Vecchio, G, Rinaldi, A, Mannironi, C, Limatola, C, Presutti, C & Mele, A 2017, 'MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity', Neurobiology of Learning and Memory, vol. 139, pp. 63-68. https://doi.org/10.1016/j.nlm.2016.12.019
Capitano, F ; Camon, J ; Licursi, V. ; Ferretti, V ; Maggi, L ; Scianni, Maria ; Del Vecchio, G. ; Rinaldi, A ; Mannironi, C. ; Limatola, C ; Presutti, C. ; Mele, A. / MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity. In: Neurobiology of Learning and Memory. 2017 ; Vol. 139. pp. 63-68.
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AU - Scianni, Maria

AU - Del Vecchio, G.

AU - Rinaldi, A

AU - Mannironi, C.

AU - Limatola, C

AU - Presutti, C.

AU - Mele, A.

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N2 - MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

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