MicroRNA-34c-5p is related to recurrence in laryngeal squamous cell carcinoma

Massimo Re, Artan Çeka, Corrado Rubini, Luigi Ferrante, Antonio Zizzi, Federico M. Gioacchini, Michele Tulli, Liana Spazzafumo, Stefano Sellari-Franceschini, Antonio D. Procopio, Fabiola Olivieri

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives/Hypothesis Altered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). We investigated the association of LSCC-related miR-34c-5p with disease-free survival and overall survival. Study Design Retrospective cohort study. Methods Expression levels of miR-34c-5p were detected in 90 LSCC formalin-fixed paraffin-embedded tissues by reverse-transcription quantitative polymerase chain reaction. Overall survival and disease-free survival were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using Cox proportional hazard analysis. Results A downregulation of miR-34c-5p expression significantly correlated with worse disease-free and overall survival. In the multivariate analysis, low miR-34c-5p expression was associated with an increased risk of recurrence. Conclusions A downregulation of miR-34c-5p in LSCC is independently associated with unfavorable disease-free survival, suggesting that miR-34c-5p might be a promising marker for evaluating the risk of recurrences. Level of Evidence NA Laryngoscope, 125:E306-E312, 2015

Original languageEnglish
Pages (from-to)E306-E312
JournalLaryngoscope
Volume125
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • biomarkers
  • Laryngeal squamous cell carcinoma
  • microRNA
  • MIR-34c-5p
  • prognosis
  • recurrence

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

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