Microrna and cardiac regeneration

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Heart diseases are a very common health problem in developed as well as developing countries. In particular, ischemic heart disease and heart failure represent a plague for the patients and for the society. Loss of cardiac tissue after myocardial infarction or dysfunctioning tissue in nonischemic cardiomyopathies may result in cardiac failure. Despite great advancements in the treatment of these diseases, there is a substantial unmet need for novel therapies, ideally addressing repair and regeneration of the damaged or lost myocardium. Along this line, cardiac cell based therapies have gained substantial attention. Three main approaches are currently under investigation: stem cell therapy with either embryonic or adult stem cells; generation of patient-specificinduced pluripotent stem cells; stimulation of endogenous regeneration trough direct reprogramming of fi broblasts into cardiomyocytes, activation of resident cardiac stem cells or induction of native resident cardiomyocytes to reenter the cell cycle. All these strategies need to be optimized since their efficiency is low. t has recently become clear that cardiac signaling and transcriptional pathways are intimately intertwined with microRNA molecules which act as modulators of cardiac development, function, and disease. Moreover, miRNA also regulates stem cell differentiation. Here we describe how miRNA may circumvent hurdles that hamper the field of cardiac regeneration and stem cell therapy, and how miRNA may result as the most suitable solution for the damaged heart.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages119-141
Number of pages23
Volume887
DOIs
Publication statusPublished - 2015

Publication series

NameAdvances in Experimental Medicine and Biology
Volume887
ISSN (Print)00652598
ISSN (Electronic)22148019

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Keywords

  • Acute myocardial infarction
  • Cardiovascular disease
  • Cell therapy
  • MicroRNA
  • Stromal cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Gnecchi, M., Pisano, F., & Bariani, R. (2015). Microrna and cardiac regeneration. In Advances in Experimental Medicine and Biology (Vol. 887, pp. 119-141). (Advances in Experimental Medicine and Biology; Vol. 887). Springer New York LLC. https://doi.org/10.1007/978-3-319-22380-3_7