TY - JOUR
T1 - MicroRNA gene expression deregulation in human breast cancer
AU - Iorio, Marilena V.
AU - Ferracin, Manuela
AU - Liu, Chang Gong
AU - Veronese, Angelo
AU - Spizzo, Riccardo
AU - Sabbioni, Silvia
AU - Magri, Eros
AU - Pedriali, Massimo
AU - Fabbri, Muller
AU - Campiglio, Manuela
AU - Ménard, Sylvie
AU - Palazzo, Juan P.
AU - Rosenberg, Anne
AU - Musiani, Piero
AU - Volinia, Stefano
AU - Nenci, Italo
AU - Calin, George A.
AU - Querzoli, Patrizia
AU - Negrini, Massimo
AU - Croce, Carlo M.
PY - 2005/8/15
Y1 - 2005/8/15
N2 - MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index.
AB - MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index.
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U2 - 10.1158/0008-5472.CAN-05-1783
DO - 10.1158/0008-5472.CAN-05-1783
M3 - Article
C2 - 16103053
AN - SCOPUS:23844555119
VL - 65
SP - 7065
EP - 7070
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 16
ER -