MicroRNA-mediated control of prostate cancer metastasis: Implications for the identification of novel biomarkers and therapeutic targets

Nicola Fenderico, Anna Casamichele, Valentina Profumo, Nadia Zaffaroni, Paolo Gandellini

Research output: Contribution to journalArticlepeer-review

Abstract

Prostate cancer is the most prevalent tumor in the male population and the second leading cause of cancerrelated death in men in Western countries. Besides genetic and epigenetic aberrations in protein coding genes, alterations in microRNAs equally contribute to prostate cancer initiation and progression. In this context, a plethora of overwhelming evidence establishes the involvement of microRNAs as essential actors in the multi-step cascade fostering a prostate cancer cell to leave the primary tumor and form secondary tumors at distant sites. Herein, we describe how specific microRNAs may impinge on the different stages of prostate cancer metastasis and review published profiling studies in which microRNA expression data have been analyzed in relation to clinical parameters of progression for the identification of novel biomarkers. We also provide evidence concerning the possibility to manipulate metastasis-related microRNA functions, either by mimicking or inhibiting them, as a highly promising strategy for the development of innovative therapeutic approaches for the advanced disease.

Original languageEnglish
Pages (from-to)1566-1584
Number of pages19
JournalCurrent Medicinal Chemistry
Volume20
Issue number12
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Antagomir
  • Circulating miRNA
  • LNA
  • Metastasis
  • MicroRNA
  • Prognosis
  • Prostate cancer
  • Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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