MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer

Marilena V. Iorio, Patrizia Casalini, Elda Tagliabue, Sylvie Ménard, Carlo M. Croce

Research output: Contribution to journalArticle

Abstract

Despite advances in detection and therapies, breast cancer is still the leading cause of cancer death in women worldwide. The etiology of this neoplasm is complex, and both genetic and environmental factors contribute to the complicated scenario. Gene profiling studies have been extensively used over the past decades as a powerful tool in defining the signature of different cancers and in predicting outcome and response to therapies. More recently, a new class of small non-coding RNAs, microRNAs (miRNAs), able to regulate gene expression binding seed sequences on the 3′UTR of mRNA targets, has been linked to several human diseases, including cancer. An increasing amount of experimental evidence shows that miRNAs are aberrantly expressed in different tumour types, and that they can have a causal role in tumourigenesis. Here, we describe and discuss the evidence supporting the association between miRNAs and breast cancer, underlining their role in the development of this neoplasia, and the impact on putative innovative therapeutical approaches.

Original languageEnglish
Pages (from-to)2753-2759
Number of pages7
JournalEuropean Journal of Cancer
Volume44
Issue number18
DOIs
Publication statusPublished - Dec 2008

Fingerprint

MicroRNAs
Breast Neoplasms
Neoplasms
Therapeutics
Small Untranslated RNA
Cause of Death
Seeds
Gene Expression
Messenger RNA
Genes

Keywords

  • Human breast cancer
  • MicroRNAs

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer. / Iorio, Marilena V.; Casalini, Patrizia; Tagliabue, Elda; Ménard, Sylvie; Croce, Carlo M.

In: European Journal of Cancer, Vol. 44, No. 18, 12.2008, p. 2753-2759.

Research output: Contribution to journalArticle

Iorio, Marilena V. ; Casalini, Patrizia ; Tagliabue, Elda ; Ménard, Sylvie ; Croce, Carlo M. / MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer. In: European Journal of Cancer. 2008 ; Vol. 44, No. 18. pp. 2753-2759.
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