Abstract
Despite advances in detection and therapies, breast cancer is still the leading cause of cancer death in women worldwide. The etiology of this neoplasm is complex, and both genetic and environmental factors contribute to the complicated scenario. Gene profiling studies have been extensively used over the past decades as a powerful tool in defining the signature of different cancers and in predicting outcome and response to therapies. More recently, a new class of small non-coding RNAs, microRNAs (miRNAs), able to regulate gene expression binding seed sequences on the 3′UTR of mRNA targets, has been linked to several human diseases, including cancer. An increasing amount of experimental evidence shows that miRNAs are aberrantly expressed in different tumour types, and that they can have a causal role in tumourigenesis. Here, we describe and discuss the evidence supporting the association between miRNAs and breast cancer, underlining their role in the development of this neoplasia, and the impact on putative innovative therapeutical approaches.
| Original language | English |
|---|---|
| Pages (from-to) | 2753-2759 |
| Number of pages | 7 |
| Journal | European Journal of Cancer |
| Volume | 44 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - Dec 2008 |
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Keywords
- Human breast cancer
- MicroRNAs
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer. / Iorio, Marilena V.; Casalini, Patrizia; Tagliabue, Elda; Ménard, Sylvie; Croce, Carlo M.
In: European Journal of Cancer, Vol. 44, No. 18, 12.2008, p. 2753-2759.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer
AU - Iorio, Marilena V.
AU - Casalini, Patrizia
AU - Tagliabue, Elda
AU - Ménard, Sylvie
AU - Croce, Carlo M.
PY - 2008/12
Y1 - 2008/12
N2 - Despite advances in detection and therapies, breast cancer is still the leading cause of cancer death in women worldwide. The etiology of this neoplasm is complex, and both genetic and environmental factors contribute to the complicated scenario. Gene profiling studies have been extensively used over the past decades as a powerful tool in defining the signature of different cancers and in predicting outcome and response to therapies. More recently, a new class of small non-coding RNAs, microRNAs (miRNAs), able to regulate gene expression binding seed sequences on the 3′UTR of mRNA targets, has been linked to several human diseases, including cancer. An increasing amount of experimental evidence shows that miRNAs are aberrantly expressed in different tumour types, and that they can have a causal role in tumourigenesis. Here, we describe and discuss the evidence supporting the association between miRNAs and breast cancer, underlining their role in the development of this neoplasia, and the impact on putative innovative therapeutical approaches.
AB - Despite advances in detection and therapies, breast cancer is still the leading cause of cancer death in women worldwide. The etiology of this neoplasm is complex, and both genetic and environmental factors contribute to the complicated scenario. Gene profiling studies have been extensively used over the past decades as a powerful tool in defining the signature of different cancers and in predicting outcome and response to therapies. More recently, a new class of small non-coding RNAs, microRNAs (miRNAs), able to regulate gene expression binding seed sequences on the 3′UTR of mRNA targets, has been linked to several human diseases, including cancer. An increasing amount of experimental evidence shows that miRNAs are aberrantly expressed in different tumour types, and that they can have a causal role in tumourigenesis. Here, we describe and discuss the evidence supporting the association between miRNAs and breast cancer, underlining their role in the development of this neoplasia, and the impact on putative innovative therapeutical approaches.
KW - Human breast cancer
KW - MicroRNAs
UR - http://www.scopus.com/inward/record.url?scp=56949084876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56949084876&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2008.09.037
DO - 10.1016/j.ejca.2008.09.037
M3 - Article
C2 - 19022662
AN - SCOPUS:56949084876
VL - 44
SP - 2753
EP - 2759
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 18
ER -