MicroRNA profiling in asthma: Potential biomarkers and therapeutic targets

Enrico Heffler, Enrico Heffler, Alessandro Allegra, Giovanni Pioggia, Giuseppe Picardi, Caterina Musolino, Sebastiano Gangemi, Sebastiano Gangemi

Research output: Contribution to journalReview articlepeer-review

Abstract

Copyright © 2017 by the American Thoracic Society. Asthma is a heterogeneous chronic inflammatory disorder in which different endotypes contribute to define clinical inflammatory phenotypes. MicroRNAs (miRNAs) are a group of minute, endogenous 22-25 nt RNA elements that join to particular mRNAs to reduce translation and increase messenger RNA degradation. miRNAs operate in post-transcriptional control and regulate physiological and pathological processes in several illnesses. The purpose of this work is to review and discuss the current knowledge about the function of miRNAs in asthma, focusing particularly on their biological properties, pathophysiologic actions, and possible use as markers and treatments for asthma.
Original languageEnglish
Pages (from-to)642-650
Number of pages9
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume57
Issue number6
DOIs
Publication statusPublished - Dec 1 2017

Keywords

  • Asthma
  • Biomarkers
  • Cytokine
  • Exosome
  • MiRNA

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