MicroRNA profiling of multiple osteochondromas: Identification of disease-specific and normal cartilage signatures

M. Zuntini, M. Salvatore, E. Pedrini, A. Parra, F. Sgariglia, A. Magrelli, D. Taruscio, L. Sangiorgi

Research output: Contribution to journalArticle

Abstract

Zuntini M, Salvatore M, Pedrini E, Parra A, Sgariglia F, Magrelli A, Taruscio D, Sangiorgi L. MicroRNA profiling of Multiple Osteochondromas: identification of disease-specific and normal cartilage signatures.Multiple osteochondroma (MO) is a rare skeletal disease characterized by the formation of multiple benign cartilage-capped bone tumors; in 1-5% of patients, a malignant transformation into peripheral chondrosarcoma may occur. This disorder is characterized by a large spectrum of germline mutations scattered along EXT1/EXT2 genes, the presence of a significant percentage of patients without alterations in EXT genes, and a large phenotypic variability. The molecular basis of MO genetic and clinical heterogeneity, including the causes underlying malignant transformation, is currently unknown. This leads to the lack of appropriate diagnostic/prognostic markers as well as of therapeutic options. Recently, specific microRNAs (miRNAs) were reported to be involved in chondrogenesis and inflammatory cartilage diseases. We therefore hypothesized a role for microRNAs in cartilaginous tumors and investigated microRNA expression in osteochondroma and normal cartilage tissues to evaluate whether they could affect osteochondromas onset and/or clinical manifestations. Our results indicate that miRNAs differentially expressed in MO samples may hamper the molecular signaling responsible for normal differentiation of chondrocytes, contributing to pathogenesis and clinical outcome. Although further studies are needed to validate our observations and to identify targets of miRNAs, this is the first study reporting on miRNA expression in growth plate and its comparison with pathological conditions.

Original languageEnglish
Pages (from-to)507-516
Number of pages10
JournalClinical Genetics
Volume78
Issue number6
DOIs
Publication statusPublished - Dec 2010

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Keywords

  • Articular cartilage
  • Endochondral ossification signaling pathways
  • Growth plate cartilage
  • MicroRNA profiling
  • Multiple Osteochondromas

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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