MicroRNAs and autoimmunity

Angela Ceribelli, Minoru Satoh, Edward K L Chan

Research output: Contribution to journalArticle

Abstract

The role of microRNAs (miRNAs) in the regulation of many physiological and pathological processes has been intensely studied in recent years. Some miRNAs, such as miR-146a and miR-182, play a dominant role in the regulation of the innate and adaptive immune responses, respectively. Many miRNAs are reportedly deregulated in autoimmune diseases, but miR-146a in particular seems to be consistently altered. The overexpression or underexpression of miRNAs can influence specific targets and pathways, leading to autoimmune disease phenotypes, and this is supported also by some in vivo studies. Targeting miRNAs could represent a valid future therapeutic option for autoimmune diseases.

Original languageEnglish
Pages (from-to)686-691
Number of pages6
JournalCurrent Opinion in Immunology
Volume24
Issue number6
DOIs
Publication statusPublished - Dec 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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