Abstract
MicroRNAs (miRNAs) are endogenous small non-coding RNAs (ncRNAs) which play important regulatory roles in physiological processes such as cellular differentiation, proliferation, development, apoptosis and stem cell self-renewal. An increasing number of papers have clearly claimed their involvement in cancer, providing, in some cases, also the molecular mechanisms implicated. Several studies led to the conclusion that miRNAs can be effectively used as anticancer agents alone or in combination with existing anticancer drugs. In particular, miRNAs can be effectively used to overcome drug resistance, one of the main factors responsible for anticancer treatment insuccess. One of the main questions remains how to modulate the expression of miRNAs in cancer cells. Interestingly, a few studies have shown that the expression of miRNAs is affected by drugs (including some drugs currently used as anticancer agents), therefore providing the rationale for an intertwined scenario in which miRNAs can be modulated by drugs and, in turn, can affect drug sensitivity of cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 351-356 |
| Number of pages | 6 |
| Journal | Frontiers in Biology |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- cancer
- chemotherapy
- miRNAs
- multidrug resistance
- transcription factor
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Biotechnology
- Genetics
- Ecology
Cite this
MicroRNAs and drug modulation in cancer : An intertwined new story. / Fanini, Francesca; Vannini, Ivan; Fabbri, Muller.
In: Frontiers in Biology, Vol. 6, No. 5, 10.2011, p. 351-356.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MicroRNAs and drug modulation in cancer
T2 - An intertwined new story
AU - Fanini, Francesca
AU - Vannini, Ivan
AU - Fabbri, Muller
PY - 2011/10
Y1 - 2011/10
N2 - MicroRNAs (miRNAs) are endogenous small non-coding RNAs (ncRNAs) which play important regulatory roles in physiological processes such as cellular differentiation, proliferation, development, apoptosis and stem cell self-renewal. An increasing number of papers have clearly claimed their involvement in cancer, providing, in some cases, also the molecular mechanisms implicated. Several studies led to the conclusion that miRNAs can be effectively used as anticancer agents alone or in combination with existing anticancer drugs. In particular, miRNAs can be effectively used to overcome drug resistance, one of the main factors responsible for anticancer treatment insuccess. One of the main questions remains how to modulate the expression of miRNAs in cancer cells. Interestingly, a few studies have shown that the expression of miRNAs is affected by drugs (including some drugs currently used as anticancer agents), therefore providing the rationale for an intertwined scenario in which miRNAs can be modulated by drugs and, in turn, can affect drug sensitivity of cancer cells.
AB - MicroRNAs (miRNAs) are endogenous small non-coding RNAs (ncRNAs) which play important regulatory roles in physiological processes such as cellular differentiation, proliferation, development, apoptosis and stem cell self-renewal. An increasing number of papers have clearly claimed their involvement in cancer, providing, in some cases, also the molecular mechanisms implicated. Several studies led to the conclusion that miRNAs can be effectively used as anticancer agents alone or in combination with existing anticancer drugs. In particular, miRNAs can be effectively used to overcome drug resistance, one of the main factors responsible for anticancer treatment insuccess. One of the main questions remains how to modulate the expression of miRNAs in cancer cells. Interestingly, a few studies have shown that the expression of miRNAs is affected by drugs (including some drugs currently used as anticancer agents), therefore providing the rationale for an intertwined scenario in which miRNAs can be modulated by drugs and, in turn, can affect drug sensitivity of cancer cells.
KW - cancer
KW - chemotherapy
KW - miRNAs
KW - multidrug resistance
KW - transcription factor
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UR - http://www.scopus.com/inward/citedby.url?scp=80053643008&partnerID=8YFLogxK
U2 - 10.1007/s11515-011-1115-9
DO - 10.1007/s11515-011-1115-9
M3 - Article
AN - SCOPUS:80053643008
VL - 6
SP - 351
EP - 356
JO - Frontiers in Biology
JF - Frontiers in Biology
SN - 1674-7984
IS - 5
ER -