MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that control gene expression at a posttranscriptional level. They are one of the most abundant class of gene regulatory molecules in multicellular organisms, and are being implicated in an increasing number of biological processes. Many miRNAs are expressed in a tissue-specific manner during development and take part in the regulation of cell-lineage decisions and morphogenesis. Moreover, much work is now highlighting their importance for malformations and disease. This chapter presents knowledge on miRNA biology, and then describes the recent findings regarding aspects of cardiovascular pathophysiology.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)