I microRNA come indicatori biologici di esposizione ambientale e occupazionale ad amianto

Translated title of the contribution: MicroRNAs as biomarkers of environmental and occupational exposure to asbestos

Claudio Minoia, Elena Sturchio, Benedetta Porro, Barbara Ficociello, Alberto Zambelli, Marcello Imbriani

Research output: Contribution to journalArticle

Abstract

Malignant mesothelioma is an aggressive cancer refractory to current therapies, the incidence of which is expected to rise in the next decades. Exposure to asbestos is a well known risk factor, as International Agency for Research and Cancer (IARC) classified this compound as group I (carcinogenic to humans). The lack of tumor biomarkers for diagnosis and medical survey plays a fundamental role for the development of a universally accepted therapeutic approach. In this review we evaluated the mechanism of asbestos carcinogenesis by analyzing activated oncogenes, genetic predisposition, and SV40 infection as cofactors. Therefore, interest has focused on microRNAs, 19-25 nucleotide-long single-stranded RNAs that negatively regulate gene expression by modulating translational efficiency of target genes involved in numerous cellular processes including development, differentiation, proliferation, apoptosis, and stress response. The analysis revealed a differential expression of miRNAs between mesothelioma and mesothelial cells, suggesting their potential role as oncogenes or tumor suppressor genes in mesothelioma oncogenesis. We have also investigated the role of polymorphism in the etiology and pathogenesis of mesothelioma, in order to evaluate the association between disease linked to asbestos exposure and genetic variability. The identification of dysregulated miRNAs or frequent genetic polymorphisms as potential diagnostic biomarkers or as prognostic factors for malignant mesothelioma could facilitate the surveillance procedure of subjects exposed to asbestos.

Translated title of the contributionMicroRNAs as biomarkers of environmental and occupational exposure to asbestos
Original languageItalian
Pages (from-to)420-434
Number of pages15
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume33
Issue number4
Publication statusPublished - Oct 2011

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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