MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease

Nadia Panera, Daniela Gnani, Annalisa Crudele, Sara Ceccarelli, Valerio Nobili, Anna Alisi

Research output: Contribution to journalArticle

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a multi-faceted condition including simple steatosis alone or associated with inflammation and ballooning (non-alcoholic steatohepatitis) and eventually fibrosis. The NAFLD incidence has increased over the last twenty years becoming the most frequent chronic liver disease in industrialized countries. Obesity, visceral adiposity, insulin resistance, and many other disorders that characterize metabolic syndrome are the major predisposing risk factors for NAFLD. Furthermore, different factors, including genetic background, epigenetic mechanisms and environmental factors, such as diet and physical exercise, contribute to NAFLD development and progression. Several lines of evidence demonstrate that specific microRNAs expression profiles are strongly associated with several pathological conditions including NAFLD. In NAFLD, microRNA deregulation in response to intrinsic genetic or epigenetic factors or environmental factors contributes to metabolic dysfunction. In this review we focused on microRNAs role both as controlled and controllers molecules in NAFLD development and/or their eventual value as non-invasive biomarkers of disease.

Original languageEnglish
Pages (from-to)15079-15086
Number of pages8
JournalWorld Journal of Gastroenterology
Volume20
Issue number41
DOIs
Publication statusPublished - Nov 7 2014

    Fingerprint

Keywords

  • Fibrosis
  • Liver steatosis
  • MicroRNAs
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this