MicroRNAs as regulators of death receptors signaling

M. Garofalo, G. L. Condorelli, C. M. Croce, G. Condorelli

Research output: Contribution to journalArticle

Abstract

Death receptors, belonging to the TNF receptor superfamily, induce apoptosis through two different pathways, one involving the effector caspases directly (type I cells or mitochondria-independent death), the other one amplifying the death signal through the mitochondrial pathway (type II cells or mitochondria-dependent death). MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate the stability or translational efficiency of targeted messenger RNAs. MiRNAs are involved in many cellular processes that are altered in cancer, such as differentiation, proliferation and apoptosis. In this review we will discuss recent findings implicating miRNAs as regulators of death receptors and pro-and antiapoptotic genes involved in programmed cell death pathways.

Original languageEnglish
Pages (from-to)200-208
Number of pages9
JournalCell Death and Differentiation
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Antiapoptotic miRs
  • Apoptosis
  • Death receptors
  • MicroRNA
  • Proapoptotic miRs
  • Tumorigenesis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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