MicroRNAs in breast cancer development and treatment

Danila Serpico, Leonardo Molino, Serena Di Cosimo

Research output: Contribution to journalArticle

Abstract

microRNAs (herein after miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. miRNAs play a well conserved and crucial role in normal biological processes, such as cell differentiation, proliferation and apoptosis through a complicated gene regulation networking. The recent rise of interest in miRNAs in cancer research is ascribed to the breakthrough of their role in many pathological processes, including malignant transformation. miRNAs signatures have been clearly defined for certain types of cancer, with correlation to tumor aggressiveness, therapy response and patient outcome. Furthermore, the use of miRNAs as therapeutic targets for cancer is currently under investigation. The aim of this review is to focus on the role of miRNAs in breast cancer development and to summarize the evidence for their potential diagnostic and therapeutic applications in clinical practice.

Original languageEnglish
Pages (from-to)595-604
Number of pages10
JournalCancer Treatment Reviews
Volume40
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Biomarkers
  • Breast cancer
  • MicroRNAs
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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