MicroRNAs in Cardiac Regeneration

Alessandra Magenta, Alessandra Rossini, Pasquale Fasanaro, Giulio Pompilio, Maurizio C. Capogrossi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The adult mammalian heart has a modest regenerative capacity. MicroRNAs, or miRNAs, represent an innovative tool in cardiac regenerative therapy because they can be easily synthesized and exploited to induce cardiac progenitor cell proliferation and differentiation, adult myocardial cell proliferation, transplanted cell engraftment in the injured heart, and differentiation into the cardiovascular lineage. MyomiRs are the most promising and exploited miRNAs in cardiac regeneration, given their capacity to induce a cardiac differentiation program both in noncardiac cells such as fibroblasts and in CPCs. The feasibility of myomiRs as a regenerative therapeutic approach was successfully demonstrated for the first time with miR-155, which was shown to reduce hCPC migration and necrosis. Additional studies are needed to adjust the chemistry and facilitate the delivery of myomiRs to make them more stable and to develop them as fully effective cardiac treatments.

Original languageEnglish
Title of host publicationMicroRNA in Regenerative Medicine
PublisherElsevier Inc.
Pages917-942
Number of pages26
ISBN (Print)9780124058583, 9780124055445
DOIs
Publication statusPublished - Dec 23 2014

Keywords

  • Cardiac stem cells
  • Heart regeneration
  • MicroRNAs
  • MiRNA-based therapy
  • MiRNAs
  • Paracrine factors

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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