MicroRNAs in ischaemic cardiovascular diseases

Research output: Contribution to journalArticlepeer-review

Abstract

microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.

Original languageEnglish
Pages (from-to)E31-E36
JournalEuropean Heart Journal, Supplement
Volume18
DOIs
Publication statusPublished - Apr 28 2016

Keywords

  • Cardiovascular diseases
  • Hypoxia
  • Ischaemia
  • microRNA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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