MicroRNAs in ischaemic cardiovascular diseases

Simona Greco; Germana Zaccagnini; Christine Voellenkle; Fabio Martelli

doi:10.1093/eurheartj/suw012

MicroRNAs in ischaemic cardiovascular diseases

Simona Greco, Germana Zaccagnini, Christine Voellenkle, Fabio Martelli

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.

Original language	English
Pages (from-to)	E31-E36
Journal	European Heart Journal, Supplement
Volume	18
DOIs	https://doi.org/10.1093/eurheartj/suw012
Publication status	Published - Apr 28 2016

Keywords

Cardiovascular diseases
Hypoxia
Ischaemia
microRNA

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1093/eurheartj/suw012

Fingerprint Dive into the research topics of 'MicroRNAs in ischaemic cardiovascular diseases'. Together they form a unique fingerprint.

Cite this

@article{c8ad0fb0c5e94ad2b0bd6ed15594a3c3,

title = "MicroRNAs in ischaemic cardiovascular diseases",

abstract = "microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.",

keywords = "Cardiovascular diseases, Hypoxia, Ischaemia, microRNA",

author = "Simona Greco and Germana Zaccagnini and Christine Voellenkle and Fabio Martelli",

year = "2016",

month = apr,

day = "28",

doi = "10.1093/eurheartj/suw012",

language = "English",

volume = "18",

pages = "E31--E36",

journal = "European Heart Journal, Supplement",

issn = "1520-765X",

publisher = "Oxford University Press",

}

TY - JOUR

T1 - MicroRNAs in ischaemic cardiovascular diseases

AU - Greco, Simona

AU - Zaccagnini, Germana

AU - Voellenkle, Christine

AU - Martelli, Fabio

PY - 2016/4/28

Y1 - 2016/4/28

N2 - microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.

AB - microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.

KW - Cardiovascular diseases

KW - Hypoxia

KW - Ischaemia

KW - microRNA

UR - http://www.scopus.com/inward/record.url?scp=84966587832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966587832&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/suw012

DO - 10.1093/eurheartj/suw012

M3 - Article

AN - SCOPUS:84966587832

VL - 18

SP - E31-E36

JO - European Heart Journal, Supplement

JF - European Heart Journal, Supplement

SN - 1520-765X

ER -