TY - JOUR
T1 - MicroRNAs in ischaemic cardiovascular diseases
AU - Greco, Simona
AU - Zaccagnini, Germana
AU - Voellenkle, Christine
AU - Martelli, Fabio
PY - 2016/4/28
Y1 - 2016/4/28
N2 - microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.
AB - microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.
KW - Cardiovascular diseases
KW - Hypoxia
KW - Ischaemia
KW - microRNA
UR - http://www.scopus.com/inward/record.url?scp=84966587832&partnerID=8YFLogxK
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U2 - 10.1093/eurheartj/suw012
DO - 10.1093/eurheartj/suw012
M3 - Article
AN - SCOPUS:84966587832
VL - 18
SP - E31-E36
JO - European Heart Journal, Supplement
JF - European Heart Journal, Supplement
SN - 1520-765X
ER -