Micrornas in prostate cancer: an overview

Daniela Vanacore, Mariarosaria Boccellino, Sabrina Rossetti, Carla Cavaliere, Carmine D'Aniello, Rossella Di Franco, Francesco Jacopo Romano, Micaela Montanari, Elvira La Mantia, Raffaele Piscitelli, Flavia Nocerino, Francesca Cappuccio, Giovanni Grimaldi, Alessandro Izzo, Luigi Castaldo, Maria Filomena Pepe, Maria Gabriella Malzone, Gelsomina Iovane, Gianluca Ametrano, Paola StiusoLucio Quagliuolo, Daniela Barberio, Sisto Perdonà, Paolo Muto, Maurizio Montella, Piera Maiolino, Bianca Maria Veneziani, Gerardo Botti, Michele Caraglia, Gaetano Facchini

Research output: Contribution to journalReview article

Abstract

Prostate cancer is the second highest cause of cancer mortality after lung tumours. In USA it affects about 2.8 million men and the incidence increases with age in many countries. Therefore, early diagnosis is a very important step for patient clinical evaluation and for a selective and efficient therapy. The study of miRNAs' functions and molecular mechanisms has brought new knowledge in biological processes of cancer. In prostate cancer there is a deregulation of several miRNAs that may function as tumour suppressors or oncogenes. The aim of this review is to analyze the progress made to our understanding of the role of miRNA dysregulation in prostate cancer tumourigenesis.

Original languageEnglish
JournalOncotarget
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Journal Article
  • Review

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    Vanacore, D., Boccellino, M., Rossetti, S., Cavaliere, C., D'Aniello, C., Di Franco, R., Romano, F. J., Montanari, M., La Mantia, E., Piscitelli, R., Nocerino, F., Cappuccio, F., Grimaldi, G., Izzo, A., Castaldo, L., Pepe, M. F., Malzone, M. G., Iovane, G., Ametrano, G., ... Facchini, G. (2017). Micrornas in prostate cancer: an overview. Oncotarget. https://doi.org/10.18632/oncotarget.16933