TY - JOUR
T1 - Micrornas in prostate cancer
T2 - an overview
AU - Vanacore, Daniela
AU - Boccellino, Mariarosaria
AU - Rossetti, Sabrina
AU - Cavaliere, Carla
AU - D'Aniello, Carmine
AU - Di Franco, Rossella
AU - Romano, Francesco Jacopo
AU - Montanari, Micaela
AU - La Mantia, Elvira
AU - Piscitelli, Raffaele
AU - Nocerino, Flavia
AU - Cappuccio, Francesca
AU - Grimaldi, Giovanni
AU - Izzo, Alessandro
AU - Castaldo, Luigi
AU - Pepe, Maria Filomena
AU - Malzone, Maria Gabriella
AU - Iovane, Gelsomina
AU - Ametrano, Gianluca
AU - Stiuso, Paola
AU - Quagliuolo, Lucio
AU - Barberio, Daniela
AU - Perdonà, Sisto
AU - Muto, Paolo
AU - Montella, Maurizio
AU - Maiolino, Piera
AU - Veneziani, Bianca Maria
AU - Botti, Gerardo
AU - Caraglia, Michele
AU - Facchini, Gaetano
PY - 2017/7
Y1 - 2017/7
N2 - Prostate cancer is the second highest cause of cancer mortality after lung tumours. In USA it affects about 2.8 million men and the incidence increases with age in many countries. Therefore, early diagnosis is a very important step for patient clinical evaluation and for a selective and efficient therapy. The study of miRNAs' functions and molecular mechanisms has brought new knowledge in biological processes of cancer. In prostate cancer there is a deregulation of several miRNAs that may function as tumour suppressors or oncogenes. The aim of this review is to analyze the progress made to our understanding of the role of miRNA dysregulation in prostate cancer tumourigenesis.
AB - Prostate cancer is the second highest cause of cancer mortality after lung tumours. In USA it affects about 2.8 million men and the incidence increases with age in many countries. Therefore, early diagnosis is a very important step for patient clinical evaluation and for a selective and efficient therapy. The study of miRNAs' functions and molecular mechanisms has brought new knowledge in biological processes of cancer. In prostate cancer there is a deregulation of several miRNAs that may function as tumour suppressors or oncogenes. The aim of this review is to analyze the progress made to our understanding of the role of miRNA dysregulation in prostate cancer tumourigenesis.
KW - Journal Article
KW - Review
U2 - 10.18632/oncotarget.16933
DO - 10.18632/oncotarget.16933
M3 - Review article
C2 - 28445135
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
ER -