MicroRNAs in rheumatoid arthritis

Angela Ceribelli, Md A. Nahid, Minoru Satoh, Edward K L Chan

Research output: Contribution to journalArticlepeer-review

Abstract

Rheumatoid arthritis (RA) is a chronic and severe autoimmune disease that affects joint tissues, bone, and cartilage. However, the pathogenesis of RA is still unclear. Autoantibodies such as rheumatoid factor and anti-cyclic citrullinated peptide are useful tools for early diagnosis, monitoring disease activity, and predicting prognosis. Recently, many groups have focused their attention on the role of microRNAs in the pathogenesis of RA, as well as a potential biomarker to monitor RA. In fact, the expression of some microRNAs, such as miR-146a, is upregulated in different cell types and tissues in RA patients. MicroRNAs in RA could also be considered as possible future targets for new therapeutic approaches.

Original languageEnglish
Pages (from-to)3667-3674
Number of pages8
JournalFEBS Letters
Volume585
Issue number23
DOIs
Publication statusPublished - Dec 1 2011

Keywords

  • Autoimmunity
  • Innate immunity
  • microRNA
  • miR-146a
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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