MicroRNAs in the pathogeny of chronic lymphocytic leukaemia

Milena S. Nicoloso, Thomas J. Kipps, Carlo M. Croce, George A. Calin

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNAs (miRNAs) have been linked to the initiation and progression of chronic lymphocytic leukaemia (CLL). The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein-coding genes. Recent studies have shown that miRNAs are the main candidates for the elusive class of CLL predisposing genes. These discoveries could be exploited for the development of useful markers for diagnosis and prognosis, as well as for the development of new RNA-based cancer therapies.

Original languageEnglish
Pages (from-to)709-716
Number of pages8
JournalBritish Journal of Haematology
Volume139
Issue number5
DOIs
Publication statusPublished - Dec 2007

Keywords

  • BCL2
  • Chronic lymphocytic leukaemia
  • MicroRNAs
  • Mutations

ASJC Scopus subject areas

  • Hematology

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