TY - JOUR
T1 - MicroRNAs linking inflamm-aging, cellular senescence and cancer
AU - Olivieri, Fabiola
AU - Rippo, Maria Rita
AU - Monsurrò, Vladia
AU - Salvioli, Stefano
AU - Capri, Miriam
AU - Procopio, Antonio Domenico
AU - Franceschi, Claudio
PY - 2013/9
Y1 - 2013/9
N2 - Epidemiological and experimental data demonstrate a strong correlation between age-related chronic inflammation (inflamm-aging) and cancer development. However, a comprehensive approach is needed to clarify the underlying molecular mechanisms. Chronic inflammation has mainly been attributed to continuous immune cells activation, but the cellular senescence process, which may involve acquisition of a senescence-associated secretory phenotype (SASP), can be another important contributor, especially in the elderly. MicroRNAs (miRs), a class of molecules involved in gene expression regulation, are emerging as modulators of some pathways, including NF-κB, mTOR, sirtuins, TGF-β and Wnt, that may be related to inflammation, cellular senescence and age-related diseases, cancer included. Interestingly, cancer development is largely avoided or delayed in centenarians, where changes in some miRs are found in plasma and leukocytes. We identified miRs that can be considered as senescence-associated (. SA-miRs), inflammation-associated (. inflamma-miRs) and cancer-associated (. onco-miRs). Here we review recent findings concerning three of them, miR-21, -126 and -146a, which target mRNAs belonging to the NF-κB pathway; we discuss their ability to link cellular senescence, inflamm-aging and cancer and their changes in centenarians, and provide an update on the possibility of using miRs to block accumulation of senescent cells to prevent formation of a microenvironment favoring cancer development and progression.
AB - Epidemiological and experimental data demonstrate a strong correlation between age-related chronic inflammation (inflamm-aging) and cancer development. However, a comprehensive approach is needed to clarify the underlying molecular mechanisms. Chronic inflammation has mainly been attributed to continuous immune cells activation, but the cellular senescence process, which may involve acquisition of a senescence-associated secretory phenotype (SASP), can be another important contributor, especially in the elderly. MicroRNAs (miRs), a class of molecules involved in gene expression regulation, are emerging as modulators of some pathways, including NF-κB, mTOR, sirtuins, TGF-β and Wnt, that may be related to inflammation, cellular senescence and age-related diseases, cancer included. Interestingly, cancer development is largely avoided or delayed in centenarians, where changes in some miRs are found in plasma and leukocytes. We identified miRs that can be considered as senescence-associated (. SA-miRs), inflammation-associated (. inflamma-miRs) and cancer-associated (. onco-miRs). Here we review recent findings concerning three of them, miR-21, -126 and -146a, which target mRNAs belonging to the NF-κB pathway; we discuss their ability to link cellular senescence, inflamm-aging and cancer and their changes in centenarians, and provide an update on the possibility of using miRs to block accumulation of senescent cells to prevent formation of a microenvironment favoring cancer development and progression.
KW - Cancer
KW - Cellular senescence
KW - Centenarians
KW - Inflamm-aging
KW - MicroRNA
KW - NF-κB
UR - http://www.scopus.com/inward/record.url?scp=84888197753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888197753&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2013.05.001
DO - 10.1016/j.arr.2013.05.001
M3 - Article
C2 - 23688930
AN - SCOPUS:84888197753
VL - 12
SP - 1056
EP - 1068
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
IS - 4
ER -