Micrornas modulate the pathogenesis of alzheimer’s disease: An in silico analysis in the human brain

Agnese Gugliandolo, Luigi Chiricosta, Virginia Boccardi, Patrizia Mecocci, Placido Bramanti, Emanuela Mazzon

Research output: Contribution to journalArticle

Abstract

MicroRNAs (miRNAs) are small RNAs involved in the post-transcriptional regulation of their target genes, causing a decrease in protein translation from the mRNA. Different miRNAs are found in the nervous system, where they are involved in its physiological functions, but altered miRNAs expression was also reported in neurodegenerative disorders, including Alzheimer’s disease (AD). AD is characterized by memory loss, cognitive function abnormalities, and various neuropsychiatric disturbances. AD hallmarks are amyloid β (Aβ) aggregates, called senile plaques, and neurofibrillary tangles (NFTs) formed by hyperphosphorylated Tau protein. In this study, we performed an in silico analysis to evaluate altered patterns of miRNAs expression in the brains of AD patients compared to healthy subjects. We found 12 miRNAs that were differentially expressed in AD compared to healthy individuals. These miRNAs have target genes involved in AD pathogenesis. In particular, some miRNAs influence Aβ production, having as target secretase and amyloid precursor protein (APP). Some miRNAs were reported to be involved in nervous system functions, and their alteration can cause neuronal dysfunction.

Original languageEnglish
Article number983
Pages (from-to)1-13
Number of pages13
JournalGenes
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Alzheimer’s disease
  • Amyloid β
  • Human brain
  • In silico analysis
  • MicroRNA

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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