Microsatellite instability and mutation analysis among southern Italian patients with colorectal carcinoma: Detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases

M. Colombino, A. Cossu, A. Arba, A. Manca, A. Curci, A. Avallone, G. Comella, G. Botti, F. Scintu, M. Amoruso, D. D'Abbicco, M. R. d'Agnessa, A. Spanu, F. Tanda, G. Palmieri

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair (MMR) and has been detected at various rates in colorectal carcinoma (CRC). The role of MSI in colorectal tumorigenesis was assessed further in this study by both microsatellite analysis of two CRC subsets [unselected patients (n = 215) and patients

Original languageEnglish
Pages (from-to)1530-1536
Number of pages7
JournalAnnals of Oncology
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 2003

Fingerprint

Microsatellite Instability
Colorectal Neoplasms
Mutation
DNA Mismatch Repair
Microsatellite Repeats
Carcinogenesis

Keywords

  • Colorectal cancer
  • Gene inactivation
  • Microsatellite instability
  • MLH1/MSH2 germline mutations

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Microsatellite instability and mutation analysis among southern Italian patients with colorectal carcinoma : Detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases. / Colombino, M.; Cossu, A.; Arba, A.; Manca, A.; Curci, A.; Avallone, A.; Comella, G.; Botti, G.; Scintu, F.; Amoruso, M.; D'Abbicco, D.; d'Agnessa, M. R.; Spanu, A.; Tanda, F.; Palmieri, G.

In: Annals of Oncology, Vol. 14, No. 10, 10.2003, p. 1530-1536.

Research output: Contribution to journalArticle

Colombino, M, Cossu, A, Arba, A, Manca, A, Curci, A, Avallone, A, Comella, G, Botti, G, Scintu, F, Amoruso, M, D'Abbicco, D, d'Agnessa, MR, Spanu, A, Tanda, F & Palmieri, G 2003, 'Microsatellite instability and mutation analysis among southern Italian patients with colorectal carcinoma: Detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases', Annals of Oncology, vol. 14, no. 10, pp. 1530-1536. https://doi.org/10.1093/annonc/mdg402
Colombino, M. ; Cossu, A. ; Arba, A. ; Manca, A. ; Curci, A. ; Avallone, A. ; Comella, G. ; Botti, G. ; Scintu, F. ; Amoruso, M. ; D'Abbicco, D. ; d'Agnessa, M. R. ; Spanu, A. ; Tanda, F. ; Palmieri, G. / Microsatellite instability and mutation analysis among southern Italian patients with colorectal carcinoma : Detection of different alterations accounting for MLH1 and MSH2 inactivation in familial cases. In: Annals of Oncology. 2003 ; Vol. 14, No. 10. pp. 1530-1536.
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