Microsatellite instability in early gastric cancer

Pasquale Battista, Raffaele Palmirotta, Paola Vitullo, Maria Concetta Verì, Cristiano Colalongo, Luciana Rigoli, Franco Fedele, Rosario Caruso, Cosimo Inferrera, Ferdinando Romano, Renato Mariani-Costantini, Luigi Frati, Alessandro Cama

Research output: Contribution to journalArticlepeer-review

Abstract

Microsatellite replication errors (RERs), consisting in random tumour-associated allele contractions or expansions, represent a frequent genetic alteration in gastric cancer and appear to be associated with important clinicopathologic parameters. To verify the role of microsatellite instability in the initial phases of gastric carcinogenesis, we analysed the status of 11 microsatellites in paired microdissected samples of tumour and unaffected mucosa from 30 cases of early gastric carcinoma. Fifteen tumours (50%) demonstrated RERs: these included 7 cases with RERs at one locus and 8 cases with RERs at 2 or more loci. Cases with 2 or more RERs were more frequent among intramucosal tumours, compared to tumours with submucosal spread (43% vs. 12%) and among tumours staged T1N0Mx, compared to tumours staged T1N1Mx (35% vs. 0%). RER-positive microsatellite typings were statistically more frequent among tumours with intramucosal extension, lower stage (T1N0Mx) and excavated growth pattern (macroscopic type III), compared to rumours with submucosal extension, higher stage (T1N1Mx) and elevated, flat or depressed growth patterns (microscopic types IIa-IIb-IIc respectively). The above findings indicate that microsatellite instability occurs early in the progression of sporadic gastric cancer and tends to be associated with good prognostic indicators.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalInternational Journal of Oncology
Volume10
Issue number1
Publication statusPublished - Jan 1997

Keywords

  • Early gastric cancer
  • MicrosatelIite
  • Mutation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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