Abstract
Microsatellite replication errors (RERs), consisting in random tumour-associated allele contractions or expansions, represent a frequent genetic alteration in gastric cancer and appear to be associated with important clinicopathologic parameters. To verify the role of microsatellite instability in the initial phases of gastric carcinogenesis, we analysed the status of 11 microsatellites in paired microdissected samples of tumour and unaffected mucosa from 30 cases of early gastric carcinoma. Fifteen tumours (50%) demonstrated RERs: these included 7 cases with RERs at one locus and 8 cases with RERs at 2 or more loci. Cases with 2 or more RERs were more frequent among intramucosal tumours, compared to tumours with submucosal spread (43% vs. 12%) and among tumours staged T1N0Mx, compared to tumours staged T1N1Mx (35% vs. 0%). RER-positive microsatellite typings were statistically more frequent among tumours with intramucosal extension, lower stage (T1N0Mx) and excavated growth pattern (macroscopic type III), compared to rumours with submucosal extension, higher stage (T1N1Mx) and elevated, flat or depressed growth patterns (microscopic types IIa-IIb-IIc respectively). The above findings indicate that microsatellite instability occurs early in the progression of sporadic gastric cancer and tends to be associated with good prognostic indicators.
| Original language | English |
|---|---|
| Pages (from-to) | 65-70 |
| Number of pages | 6 |
| Journal | International Journal of Oncology |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - Jan 1997 |
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Keywords
- Early gastric cancer
- MicrosatelIite
- Mutation
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Microsatellite instability in early gastric cancer. / Battista, Pasquale; Palmirotta, Raffaele; Vitullo, Paola; Verì, Maria Concetta; Colalongo, Cristiano; Rigoli, Luciana; Fedele, Franco; Caruso, Rosario; Inferrera, Cosimo; Romano, Ferdinando; Mariani-Costantini, Renato; Frati, Luigi; Cama, Alessandro.
In: International Journal of Oncology, Vol. 10, No. 1, 01.1997, p. 65-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microsatellite instability in early gastric cancer
AU - Battista, Pasquale
AU - Palmirotta, Raffaele
AU - Vitullo, Paola
AU - Verì, Maria Concetta
AU - Colalongo, Cristiano
AU - Rigoli, Luciana
AU - Fedele, Franco
AU - Caruso, Rosario
AU - Inferrera, Cosimo
AU - Romano, Ferdinando
AU - Mariani-Costantini, Renato
AU - Frati, Luigi
AU - Cama, Alessandro
PY - 1997/1
Y1 - 1997/1
N2 - Microsatellite replication errors (RERs), consisting in random tumour-associated allele contractions or expansions, represent a frequent genetic alteration in gastric cancer and appear to be associated with important clinicopathologic parameters. To verify the role of microsatellite instability in the initial phases of gastric carcinogenesis, we analysed the status of 11 microsatellites in paired microdissected samples of tumour and unaffected mucosa from 30 cases of early gastric carcinoma. Fifteen tumours (50%) demonstrated RERs: these included 7 cases with RERs at one locus and 8 cases with RERs at 2 or more loci. Cases with 2 or more RERs were more frequent among intramucosal tumours, compared to tumours with submucosal spread (43% vs. 12%) and among tumours staged T1N0Mx, compared to tumours staged T1N1Mx (35% vs. 0%). RER-positive microsatellite typings were statistically more frequent among tumours with intramucosal extension, lower stage (T1N0Mx) and excavated growth pattern (macroscopic type III), compared to rumours with submucosal extension, higher stage (T1N1Mx) and elevated, flat or depressed growth patterns (microscopic types IIa-IIb-IIc respectively). The above findings indicate that microsatellite instability occurs early in the progression of sporadic gastric cancer and tends to be associated with good prognostic indicators.
AB - Microsatellite replication errors (RERs), consisting in random tumour-associated allele contractions or expansions, represent a frequent genetic alteration in gastric cancer and appear to be associated with important clinicopathologic parameters. To verify the role of microsatellite instability in the initial phases of gastric carcinogenesis, we analysed the status of 11 microsatellites in paired microdissected samples of tumour and unaffected mucosa from 30 cases of early gastric carcinoma. Fifteen tumours (50%) demonstrated RERs: these included 7 cases with RERs at one locus and 8 cases with RERs at 2 or more loci. Cases with 2 or more RERs were more frequent among intramucosal tumours, compared to tumours with submucosal spread (43% vs. 12%) and among tumours staged T1N0Mx, compared to tumours staged T1N1Mx (35% vs. 0%). RER-positive microsatellite typings were statistically more frequent among tumours with intramucosal extension, lower stage (T1N0Mx) and excavated growth pattern (macroscopic type III), compared to rumours with submucosal extension, higher stage (T1N1Mx) and elevated, flat or depressed growth patterns (microscopic types IIa-IIb-IIc respectively). The above findings indicate that microsatellite instability occurs early in the progression of sporadic gastric cancer and tends to be associated with good prognostic indicators.
KW - Early gastric cancer
KW - MicrosatelIite
KW - Mutation
UR - http://www.scopus.com/inward/record.url?scp=12644310317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12644310317&partnerID=8YFLogxK
M3 - Article
C2 - 21533345
AN - SCOPUS:12644310317
VL - 10
SP - 65
EP - 70
JO - International Journal of Oncology
JF - International Journal of Oncology
SN - 1019-6439
IS - 1
ER -