Microsatellite instability in thyroid tumours and tumour-like lesions

D. Lazzereschi, R. Palmirotta, A. Ranieri, L. Ottini, M. C. Verì, A. Cama, F. Cetta, F. Nardi, G. Colletta, R. Mariani-Costantini

Research output: Contribution to journalArticlepeer-review

Abstract

Fifty-one thyroid tumours and tumour-like lesions were analysed for instability at ten dinucleotide microsatellite loci and at two coding mononucleotide repeats within the transforming growth factor β (TGF-β) type II receptor (TβRII) and insulin-like growth factor II (IGF-II) receptor (IGFIIR) genes respectively. Microsatellite instability (MI) was detected in 11 out of 51 cases (21.5%), including six (11.7%) with MI at one or two loci and five (9.8%) with MI at three or more loci (RER+ phenotype). No mutations in the TβRII and IGFIIR repeats were observed. The overall frequency of MI did not significantly vary in relation to age, gender, benign versus malignant status and tumour size. However, widespread MI was significantly more frequent in follicular adenomas and carcinomas than in papillary and Hurthle cell tumours: three out of nine tumours of follicular type (33.3%) resulted in replication error positive (RER+), versus 1 out of 29 papillary carcinomas (3.4%, P = 0.01), and zero out of eight Hurthle cell neoplasms. Regional lymph node metastases were present in five MI-negative primary cancers and resulted in MI-positive in two cases.

Original languageEnglish
Pages (from-to)340-345
Number of pages6
JournalBritish Journal of Cancer
Volume79
Issue number2
Publication statusPublished - 1999

Keywords

  • Insulin-like growth factor II receptor gene
  • Lymph node metastasis
  • RER phenotype
  • Thyroid tumour: microsatellite instability
  • Transforming growth factor β type II receptor gene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint

Dive into the research topics of 'Microsatellite instability in thyroid tumours and tumour-like lesions'. Together they form a unique fingerprint.

Cite this