Abstract
Background: Hepatic steatosis may promote progression of chronic hepatitis C (CHC). Microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of ApoB lipoprotein and is implicated in hepatitis C virus (HCV)-related steatosis. The MTP -493G/T polymorphism may promote liver fat accumulation, but its role in HCV-related steatosis is still unclear. Methods: Two hundred ninety-eight CHC patients were studied and genotyped for MTP -493G/T variants. Hepatic MTP mRNA expression and activity were determined in a subgroup. Results: Patients with grades 2/3 steatosis were older, had a higher body mass index (BMI), more advanced fibrosis and lower MTP mRNA expression and carried more often HCV genotype 3 and the MTP T allele. Age, BMI, HCV-3 and MTP T allele [odds ratio (OR) 2.05; 95% confidence interval (CI) 1.2-3.53; P = 0.009] were independent risk factors for steatosis grades 2/3, and in HCV genotype non-3 patients, the MTP T allele was the strongest predictor for steatosis grade 2/3 (OR 2.17; 95% CI 1.22-3.86; P = 0.008). Moreover, TT carriers had higher high-density lipoprotein (65.6 ± 14.6 vs 56.1 ± 16.2 mg/dl; P = 0.003) and apolipoprotein AI (1.80 ± 0.3 vs 1.60 ± 0.3g/L; P = 0.005) levels than G allele carriers. Conclusions: Chronic hepatitis C patients with the MTP -493T allele reveal higher grades of steatosis, indicating a relevant contribution to liver fat accumulation, particularly in HCV non-3 patients.
| Original language | English |
|---|---|
| Pages (from-to) | 557-565 |
| Number of pages | 9 |
| Journal | Liver International |
| Volume | 29 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Genetic risk
- Hepatitis C
- Lipid metabolism
- Metabolic syndrome
- Microsomal triglyceride transfer protein
- Steatosis
ASJC Scopus subject areas
- Hepatology
Cite this
Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C. / Mirandola, Silvia; Österreicher, Christoph H.; Marcolongo, Moira; Datz, Christian; Aigner, Elmar; Schlabrakowski, Anne; Realdon, Stefano; Gerotto, Martina; Alberti, Alfredo; Stickel, Felix.
In: Liver International, Vol. 29, No. 4, 2009, p. 557-565.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C
AU - Mirandola, Silvia
AU - Österreicher, Christoph H.
AU - Marcolongo, Moira
AU - Datz, Christian
AU - Aigner, Elmar
AU - Schlabrakowski, Anne
AU - Realdon, Stefano
AU - Gerotto, Martina
AU - Alberti, Alfredo
AU - Stickel, Felix
PY - 2009
Y1 - 2009
N2 - Background: Hepatic steatosis may promote progression of chronic hepatitis C (CHC). Microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of ApoB lipoprotein and is implicated in hepatitis C virus (HCV)-related steatosis. The MTP -493G/T polymorphism may promote liver fat accumulation, but its role in HCV-related steatosis is still unclear. Methods: Two hundred ninety-eight CHC patients were studied and genotyped for MTP -493G/T variants. Hepatic MTP mRNA expression and activity were determined in a subgroup. Results: Patients with grades 2/3 steatosis were older, had a higher body mass index (BMI), more advanced fibrosis and lower MTP mRNA expression and carried more often HCV genotype 3 and the MTP T allele. Age, BMI, HCV-3 and MTP T allele [odds ratio (OR) 2.05; 95% confidence interval (CI) 1.2-3.53; P = 0.009] were independent risk factors for steatosis grades 2/3, and in HCV genotype non-3 patients, the MTP T allele was the strongest predictor for steatosis grade 2/3 (OR 2.17; 95% CI 1.22-3.86; P = 0.008). Moreover, TT carriers had higher high-density lipoprotein (65.6 ± 14.6 vs 56.1 ± 16.2 mg/dl; P = 0.003) and apolipoprotein AI (1.80 ± 0.3 vs 1.60 ± 0.3g/L; P = 0.005) levels than G allele carriers. Conclusions: Chronic hepatitis C patients with the MTP -493T allele reveal higher grades of steatosis, indicating a relevant contribution to liver fat accumulation, particularly in HCV non-3 patients.
AB - Background: Hepatic steatosis may promote progression of chronic hepatitis C (CHC). Microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of ApoB lipoprotein and is implicated in hepatitis C virus (HCV)-related steatosis. The MTP -493G/T polymorphism may promote liver fat accumulation, but its role in HCV-related steatosis is still unclear. Methods: Two hundred ninety-eight CHC patients were studied and genotyped for MTP -493G/T variants. Hepatic MTP mRNA expression and activity were determined in a subgroup. Results: Patients with grades 2/3 steatosis were older, had a higher body mass index (BMI), more advanced fibrosis and lower MTP mRNA expression and carried more often HCV genotype 3 and the MTP T allele. Age, BMI, HCV-3 and MTP T allele [odds ratio (OR) 2.05; 95% confidence interval (CI) 1.2-3.53; P = 0.009] were independent risk factors for steatosis grades 2/3, and in HCV genotype non-3 patients, the MTP T allele was the strongest predictor for steatosis grade 2/3 (OR 2.17; 95% CI 1.22-3.86; P = 0.008). Moreover, TT carriers had higher high-density lipoprotein (65.6 ± 14.6 vs 56.1 ± 16.2 mg/dl; P = 0.003) and apolipoprotein AI (1.80 ± 0.3 vs 1.60 ± 0.3g/L; P = 0.005) levels than G allele carriers. Conclusions: Chronic hepatitis C patients with the MTP -493T allele reveal higher grades of steatosis, indicating a relevant contribution to liver fat accumulation, particularly in HCV non-3 patients.
KW - Genetic risk
KW - Hepatitis C
KW - Lipid metabolism
KW - Metabolic syndrome
KW - Microsomal triglyceride transfer protein
KW - Steatosis
UR - http://www.scopus.com/inward/record.url?scp=62749100684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62749100684&partnerID=8YFLogxK
U2 - 10.1111/j.1478-3231.2008.01892.x
DO - 10.1111/j.1478-3231.2008.01892.x
M3 - Article
C2 - 19018985
AN - SCOPUS:62749100684
VL - 29
SP - 557
EP - 565
JO - Liver International
JF - Liver International
SN - 1478-3223
IS - 4
ER -