Microsurgeon Hirudo medicinalis as a natural bioshuttle for spontaneous mass vaccination against influenza a virus

Sara Samadi-Shams, Sina Atashpaz, Sajjad Khani MSc

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Recent report on existence of a stem region of hemagglutinin has arisen new hopes for vaccination of influenza A as it consist of a conserve fusion peptide shared across several influenza subtypes and can be targeted by human immune system. Methods: Given that traditional vaccination based on live attenuated viruses often fails to surpass such viral infection, a great deal of attention has been devoted to develop a safe yet efficient system for vaccination influenza A. We believe that a natural bioshuttle can be recruited for spontaneous mass vaccination. Results: Thus, here, we hypothesize that a bioengineered transgenic Hirudo medicinalis can be considered as an alive bioshuttle for in-situ vaccination against influenza A virus. By introducing the designated gene(s) encoding the target fragment (i.e., stem region of hemagglutinin), this microsurgeon can act as a rapid microproducer of viral proteins for in-house mass vaccination through imparting the necessary proteins such as those, naturally presented in leech's saliva. Conclusion: This peculiar bioshuttle can be easily exploited as a medical modality choice at home resulting in greater patient compliance.

Original languageEnglish
Pages (from-to)189-191
Number of pages3
JournalBioImpacts
Volume1
Issue number3
DOIs
Publication statusPublished - 2011

Keywords

  • Hirudo medicinalis
  • Influenza a virus
  • Vaccination

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmaceutical Science
  • Biochemistry, Genetics and Molecular Biology(all)

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