Microvascular blood flow regulation impairments in hypertensive obese people

T. Mastantuono, D. Lapi, L. Battiloro, M. Cesarelli, G. D'Addio, L. Iuppariello, A. Colantuoni

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hypertension causes several microvascular alterations, leading to inadequate blood supply to tissues and target-organ damage. The present study was aimed to investigate microvascular skin blood flow and related oscillations in hypertensive obese subjects. Twenty-eight controls and twenty-seven hypertensive patients were recruited from our Outpatient Clinics. Anthropometric measurements were evaluated and bioimpedance analysis was performed. Finally, skin microvascular blood flow was measured by a laser Doppler flowmeter and oscillations in blood flow were analyzed by power spectrum analysis. Newly diagnosed hypertensive subjects showed lower mean skin blood flow as well as lower related total power spectral density compared to the controls. In these patients, moreover, power spectral analysis of microvascular oscillations indicate a lower spectral density of the frequency component related to myogenic activity compared to controls. Therefore, hypertension appears to be associated to myogenic impairments, causing changes in microvascular modulation and tissue perfusion.

Original languageEnglish
Title of host publication2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014
PublisherIEEE Computer Society
Pages191-192
Number of pages2
ISBN (Print)9781479939695
DOIs
Publication statusPublished - 2014
Event2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014 - Trento, Italy
Duration: May 25 2014May 28 2014

Other

Other2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014
CountryItaly
CityTrento
Period5/25/145/28/14

Keywords

  • blood flow oscillations
  • Hypertension
  • obesity
  • skin microcirculation
  • spectral analysis

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Mastantuono, T., Lapi, D., Battiloro, L., Cesarelli, M., D'Addio, G., Iuppariello, L., & Colantuoni, A. (2014). Microvascular blood flow regulation impairments in hypertensive obese people. In 2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014 (pp. 191-192). [6847584] IEEE Computer Society. https://doi.org/10.1109/ESGCO.2014.6847584