Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis

Research output: Contribution to journalArticlepeer-review

Abstract

We suggest the use of MicroCLOTS (microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome) as a new name for severe pulmonary coronavirus disease 2019 (COVID-19). We hypothesise that, in predisposed individuals, alveolar viral damage is followed by an inflammatory reaction and by microvascular pulmonary thrombosis. This progressive endothelial thromboinflammatory syndrome may also involve the microvascular bed of the brain and other vital organs, leading to multiple organ failure and death. Future steps in the understanding of the disease and in the identification of treatments may benefit from this definition and hypothesised sequence of events.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.
Volume22
Issue number2
Publication statusE-pub ahead of print - Apr 15 2020

Fingerprint Dive into the research topics of 'Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis'. Together they form a unique fingerprint.

Cite this