Microvascular density and endothelial area correlate with Ki-67 proliferative rate in the canine non-Hodgkin's lymphoma spontaneous model

Rosa Patruno, Nicola Zizzo, Alfredo Zito, Vittorio Catalano, Paolo Valerio, Valentina Pellecchia, Eustachio D'errico, Francesco Mazzone, Domenico Ribatti, Girolamo Ranieri

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental and clinical data indicate that tumor progression and malignancy are associated with increased angiogenesis and higher Ki-67 proliferation rate. Furthermore, increased angiogenesis and higher Ki-67 proliferation rate are associated with a poor prognosis, in both solid and hematological malignancies. However, no data have been published concerning the relationship between angiogenesis and Ki-67 proliferation rate in canine non-Hodgkin's lymphoma (NHL), a neoplasm that shares several biological and clinical characteristics with human NHL. This study has evaluated the relationship between angiogenesis and Ki-67 proliferation rate in a series of 58 canine NHL. Results showed that microvascular density (MVD), endothelial area (EA) and Ki-67 (MIB-1) are significantly correlated and that all the above indexes paralleled with the malignancy degree of NHL. These data suggest a biological link between angiogenesis and Ki-67 proliferation rate in canine NHL, which represents an interesting model to study the role of angiogenesis and proliferative activity as inter-species pathways of tumoral malignancy and biological aggressiveness.

Original languageEnglish
Pages (from-to)1138-1143
Number of pages6
JournalLeukemia and Lymphoma
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Angiogenesis
  • Dog lymphoma
  • Endothelial area
  • Immunohistochemistry
  • Ki-67 proliferation rate
  • Microvascular density

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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